SB 505124

Cat. No. 3263

SB 505124 C20H21N3O2 [694433-59-5]

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Chemical Name: 2-[4-(1,3-Benzodioxol-5-yl)-2-(1,1-dimethylethyl)-1H-imidazol-5-yl]-6-methyl-pyridine

Biological Activity

Selective inhibitor of transforming growth factor-β type I receptor (ALK5), ALK4 and ALK7 (IC50 values are 47 and 129 nM for ALK5 and ALK4 respectively). Selectively inhibits signaling from TGF-β and activin; does not inhibit other ALK family members.

Technical Data

M.Wt:
335.4
Formula:
C20H21N3O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in 1eq. HCl
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
694433-59-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Noma et al (2008) The essential role of fibroblasts in esophageal squamous cell carcinoma-induced angiogenesis. Gastroenterology 134 1981. PMID: 18439605.

Hu et al (2005) Reactive oxygen species production via NADPH oxidase mediates TGF-β-induced cytoskeletal alterations in endothelial cells. Am.J.Physiol.Renal Physiol. 289 F816. PMID: 16159901.

Byfield et al (2004) SB-505124 is a selective inhibitor of transforming growth factor-β type I receptors ALK4, ALK5, and ALK7. Mol.Pharmacol. 65 744. PMID: 14978253.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for SB 505124 include:

Boxtel et al (2015) A Temporal Window for Signal Activation Dictates the Dimensions of a Nodal Signaling Domain. Dev Cell 35 175. PMID: 26506307.

Ramel and Hill (2013) The ventral to dorsal BMP activity gradient in the early zebrafish embryo is determined by graded expression of BMP ligands. Dev Biol 378 170. PMID: 23499658.

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Keywords: SB 505124, supplier, SB505124, tgfβ, tgfbeta, tgfb, tgfbrI, tgfbetarI, tgfβrI, receptors, transforming, growth, factors, alk5, alk4, alk7, inhibitors, inhibits, Tocris Bioscience, TGF-β Receptor Inhibitor products

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