Cat. No. 3260
Alternative Name: 4'-Epidoxorubicin
Chemical Name: (8S,10S)-10-[(3-Amino-2,3,6-trideox
Biological ActivityAntibiotic antitumor agent. Inhibits the synthesis and function of DNA (IC50 = 62.7 μM in rat glioblastoma cell lines) and inhibits the relaxing property of topoisomerase II.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Schott and Robert (1989) Comparative activity of anthracycline 13-dihydrometabolites against rat glioblastoma cells in culture. Biochem.Pharmacol. 38 4069. PMID: 2597184.
Cersosimo et al (1986) Epirubicin: a review of pharmacology, clinical activity, and adverse effects of an adriamycin analogue. J.Clin.Oncol. 4 425. PMID: 3005521.
Spadari et al (1986) DNA polymerases and DNA topoisomerases as targets for the development of anticancer drugs. Anticancer Res. 6 935. PMID: 3026237.
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Citations are publications that use Tocris products. Selected citations for Epirubicin hydrochloride include:
Robinson et al (2013) RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs. PLoS One 8 e78641. PMID: 24265703.
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Keywords: Epirubicin hydrochloride, supplier, inhibitors, inhibits, DNA, synthesis, function, topoisomerase, II, Isomerases, antibiotics, 4-Epidoxorubicin, chemotherapeutics, Tocris Bioscience, DNA, RNA and Protein Synthesis Inhibitor products
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