Epirubicin hydrochloride

Cat. No. 3260

Epirubicin hydrochloride C27H29NO11.HCl [56390-09-1]

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Alternative Name: 4'-Epidoxorubicin

Chemical Name: (8S,10S)-10-[(3-Amino-2,3,6-trideoxy-α-L-arabino-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,12-naphthacenedione hydrochloride

Biological Activity

Antibiotic antitumor agent. Inhibits the synthesis and function of DNA (IC50 = 62.7 μM in rat glioblastoma cell lines) and inhibits the relaxing property of topoisomerase II.

Technical Data

M.Wt:
579.98
Formula:
C27H29NO11.HCl
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
>97 %
Storage:
Desiccate at +4°C
CAS No:
56390-09-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Schott and Robert (1989) Comparative activity of anthracycline 13-dihydrometabolites against rat glioblastoma cells in culture. Biochem.Pharmacol. 38 4069. PMID: 2597184.

Cersosimo et al (1986) Epirubicin: a review of pharmacology, clinical activity, and adverse effects of an adriamycin analogue. J.Clin.Oncol. 4 425. PMID: 3005521.

Spadari et al (1986) DNA polymerases and DNA topoisomerases as targets for the development of anticancer drugs. Anticancer Res. 6 935. PMID: 3026237.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Epirubicin hydrochloride include:

Robinson et al (2013) RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs. PLoS One 8 e78641. PMID: 24265703.

Do you know of a great paper that uses Epirubicin hydrochloride from Tocris? If so please let us know.

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Keywords: Epirubicin hydrochloride, supplier, inhibitors, inhibits, DNA, synthesis, function, topoisomerase, II, Isomerases, antibiotics, 4-Epidoxorubicin, chemotherapeutics, Tocris Bioscience, DNA, RNA and Protein Synthesis Inhibitor products

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