Cat. No. 3252
Chemical Name: N-Methyl-N-[[3-(4-pyridinyl)phenyl]
Biological ActivityPotent inhibitor of α/β-hydrolase domain 6 (ABHD6) (IC50 = 70 nM), an enzyme which catalyzes the hydrolysis of 2-arachidonylglycerol (Cat. No. 1298).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Blankman et al (2007) A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonylglycerol. Chem.Biol. 14 1347. PMID: 18096503.
Li et al (2007) A functional proteomic strategy to discover inhibitors for uncharacterized hydrolases. J.Am.Chem.Soc. 129 9594. PMID: 17629278.
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Citations are publications that use Tocris products. Selected citations for WWL 70 include:
Tchantchou and Zhang (2013) Selective inhibition of alpha/beta-hydrolase domain 6 attenuates neurodegeneration, alleviates blood brain barrier breakdown, and improves functional recovery in a mouse model of traumatic brain injury. J Neurotrauma 30 565. PMID: 23151067.
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Keywords: WWL 70, supplier, WWL70, potent, ABHD6, inhibitors, αβ-hydrolase, domain, 6, alphabeta-hydrolase, endocannabinoids, 2-arachidonylglycerol, hydrolysis, inhibits, Tocris Bioscience, Other Hydrolase Inhibitor products
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