WWL 70

Cat. No. 3252

WWL 70 C27H23N3O3 [947669-91-2]

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Chemical Name: N-Methyl-N-[[3-(4-pyridinyl)phenyl]methyl]-4'-(aminocarbonyl)[1,1'-biphenyl]-4-yl carbamic acid ester

Biological Activity

Potent inhibitor of α/β-hydrolase domain 6 (ABHD6) (IC50 = 70 nM), an enzyme which catalyzes the hydrolysis of 2-arachidonylglycerol (Cat. No. 1298).

Technical Data

M.Wt:
437.49
Formula:
C27H23N3O3
Solubility:
Soluble to 10 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
947669-91-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Blankman et al (2007) A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonylglycerol. Chem.Biol. 14 1347. PMID: 18096503.

Li et al (2007) A functional proteomic strategy to discover inhibitors for uncharacterized hydrolases. J.Am.Chem.Soc. 129 9594. PMID: 17629278.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for WWL 70 include:

Tchantchou and Zhang (2013) Selective inhibition of alpha/beta-hydrolase domain 6 attenuates neurodegeneration, alleviates blood brain barrier breakdown, and improves functional recovery in a mouse model of traumatic brain injury. J Neurotrauma 30 565. PMID: 23151067.

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Keywords: WWL 70, supplier, WWL70, potent, ABHD6, inhibitors, αβ-hydrolase, domain, 6, alphabeta-hydrolase, endocannabinoids, 2-arachidonylglycerol, hydrolysis, inhibits, Tocris Bioscience, Other Hydrolase Inhibitor products

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