Cat. No. 3252
Chemical Name: N-Methyl-N-[[3-(4-pyridinyl)phenyl]
Biological ActivityPotent inhibitor of α/β-hydrolase domain 6 (ABHD6) (IC50 = 70 nM), an enzyme which catalyzes the hydrolysis of 2-arachidonylglycerol (Cat. No. 1298).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Blankman et al (2007) A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonylglycerol. Chem.Biol. 14 1347. PMID: 18096503.
Li et al (2007) A functional proteomic strategy to discover inhibitors for uncharacterized hydrolases. J.Am.Chem.Soc. 129 9594. PMID: 17629278.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for WWL 70 include:
Tchantchou and Zhang (2013) Selective inhibition of alpha/beta-hydrolase domain 6 attenuates neurodegeneration, alleviates blood brain barrier breakdown, and improves functional recovery in a mouse model of traumatic brain injury. J Neurotrauma 30 565. PMID: 23151067.
Do you know of a great paper that uses WWL 70 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: WWL 70, supplier, WWL70, potent, ABHD6, inhibitors, αβ-hydrolase, domain, 6, alphabeta-hydrolase, endocannabinoids, 2-arachidonylglycerol, hydrolysis, inhibits, Tocris Bioscience, Other Hydrolase Inhibitor products
Find multiple products by catalog number
New Products in this Area
Non-competitive MAGL inhibitor(S)-Crizotinib
Potent MTH1 inhibitorTPPU
Potent soluble epoxide hydrolase inhibitor; orally bioavailable and brain penetrantJZP 430
Potent and irreversible α/β-hydrolase domain 6 (ABHD6) inhibitor
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.