Chlormethiazole hydrochloride

Cat. No. 0881

Chlormethiazole hydrochloride C6H8ClNS.HCl [6001-74-7]

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Chemical Name: 5-(2-Chloroethyl)-4-methylthiazole hydrochloride

Biological Activity

Sedative and anticonvulsant which is neuroprotective in a number of animal models. Prevents the degeneration of serotonergic nerve terminals induced by MDMA ('Ecstasy').

Technical Data

M.Wt:
198.11
Formula:
C6H8ClNS.HCl
Solubility:
Soluble to 100 mM in water
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
6001-74-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Cross et al (1995) The protective action of chloromethiazole against ischaemia induced neurodegeneration in gerbils when infused at doses having little sedative or anticonvulsant activity. Br.J.Pharmacol. 114 1625. PMID: 7599932.

Hewitt and Green (1994) Chloromethiazole, dizocilpine and haloperidol prevent the degeneration of serotonergic nerve terminals induced by the administration of MDMA ('Ecstasy') to rats. Neuropharmacology 33 1589. PMID: 7539115.

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Keywords: Chlormethiazole hydrochloride, supplier, Potentiates, GABAA, receptor, function, Receptors, modulators, Tocris Bioscience, GABAA Receptor Modulator products

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