Cat. No. 0881
Chemical Name: 5-(2-Chloroethyl)-4-methylthiazole hydrochloride
Biological ActivitySedative and anticonvulsant which is neuroprotective in a number of animal models. Prevents the degeneration of serotonergic nerve terminals induced by MDMA ('Ecstasy').
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Cross et al (1995) The protective action of chloromethiazole against ischaemia induced neurodegeneration in gerbils when infused at doses having little sedative or anticonvulsant activity. Br.J.Pharmacol. 114 1625. PMID: 7599932.
Hewitt and Green (1994) Chloromethiazole, dizocilpine and haloperidol prevent the degeneration of serotonergic nerve terminals induced by the administration of MDMA ('Ecstasy') to rats. Neuropharmacology 33 1589. PMID: 7539115.
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Keywords: Chlormethiazole hydrochloride, supplier, Potentiates, GABAA, receptor, function, Receptors, modulators, Tocris Bioscience, GABAA Receptor Modulator products