KC 12291 hydrochloride
Cat. No. 3251
Chemical Name: 3,4-Dimethoxy-N-methyl-N-[3-[(5-phe
Biological ActivityOrally active atypical voltage-gated sodium channel blocker. Inhibits sustained sodium currents (INaL) and prevents diastolic contracture in isolated atria in vitro (IC50 values are 9.6 and 0.55 - 0.79 μM respectively). Displays anti-ischemic, bradycardic and cardioprotective activity in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Letienne et al (2006) Pharmacological characterisation of sodium channels in sinoatrial node pacemaking in the rat heart. Eur.J.Pharmacol. 530 243. PMID: 16368090.
John et al (2004) KC 12291: an atypical sodium channel blocker with myocardial antiischemic properties. Cardiovasc.Drug Rev. 22 17. PMID: 14978516.
Tamareille et al (2002) Anti-ischemic compound KC 12291 prevents diastolic contracture in isolated atria by blockade of voltage-gated sodium channels. J.Cardiovasc.Pharmacol. 40 346. PMID: 12198320.
Decking et al (1998) Cardioprotective actions of KC 12291. Naunyn-Schmied.Arch.Pharmacol. 358 547.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses KC 12291 hydrochloride from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: KC 12291 hydrochloride, supplier, Orally, active, atypical, Na+, blockers, cardioprotective, Sodium, NaV, Channels, voltage-gated, voltage-dependent, KC12291, hydrochloride, Tocris Bioscience, Voltage-gated Sodium (NaV) Channel Blocker products
Find multiple products by catalog number
New Products in this Area
Potent and selective Nav1.7 channel blockerOD1
Potent hNav1.4, rNav1.6 and rNav1.7 channel activatorMambalgin 1
Selective ASIC1a inhibitor; analgesic
October 30 - November 3, 2016
Boston, MA, USA