KC 12291 hydrochloride

Cat. No. 3251

KC 12291 hydrochloride C22H27N3O3S.HCl [181936-98-1]

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Chemical Name: 3,4-Dimethoxy-N-methyl-N-[3-[(5-phenyl-1,2,4-thiadiazol-3-yl)oxy]propyl]benzeneethanamine hydrochloride

Biological Activity

Orally active atypical voltage-gated sodium channel blocker. Inhibits sustained sodium currents (INaL) and prevents diastolic contracture in isolated atria in vitro (IC50 values are 9.6 and 0.55 - 0.79 μM respectively). Displays anti-ischemic, bradycardic and cardioprotective activity in vivo.

Technical Data

Soluble to 25 mM in water and to 50 mM in DMSO
>97 %
Desiccate at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Letienne et al (2006) Pharmacological characterisation of sodium channels in sinoatrial node pacemaking in the rat heart. Eur.J.Pharmacol. 530 243. PMID: 16368090.

John et al (2004) KC 12291: an atypical sodium channel blocker with myocardial antiischemic properties. Cardiovasc.Drug Rev. 22 17. PMID: 14978516.

Tamareille et al (2002) Anti-ischemic compound KC 12291 prevents diastolic contracture in isolated atria by blockade of voltage-gated sodium channels. J.Cardiovasc.Pharmacol. 40 346. PMID: 12198320.

Decking et al (1998) Cardioprotective actions of KC 12291. Naunyn-Schmied.Arch.Pharmacol. 358 547.

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Keywords: KC 12291 hydrochloride, supplier, Orally, active, atypical, Na+, blockers, cardioprotective, Sodium, NaV, Channels, voltage-gated, voltage-dependent, KC12291, hydrochloride, Tocris Bioscience, Voltage-gated Sodium (NaV) Channel Blocker products

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