VU 0155041

Cat. No. 3248

VU 0155041 C14H15Cl2NO3 [1093757-42-6]

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Chemical Name: cis-2-[[(3,5-Dichlorophenyl)amino]carbonyl]cyclohexanecarboxylic acid

Biological Activity

Potent, positive allosteric modulator/allosteric agonist at mGlu4 receptors (EC50 = 798 and 693 nM at human and rat mGlu4 receptors respectively). Active in in vivo models of Parkinson's disease following i.c.v. administration. Also available as sodium salt (Cat. No. 3311).

Technical Data

M.Wt:
316.18
Formula:
C14H15Cl2NO3
Solubility:
Soluble to 100 mM in 1eq. NaOH and to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
1093757-42-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Niswender et al (2008) Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4. Mol.Pharmacol. 74 1345. PMID: 18664603.

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Keywords: VU 0155041, supplier, Potent, positive, allosteric, mGlu4, mGluR4, agonists, mGlur, Group, III, Receptors, Glutamate, Metabotropic, VU0155041, Tocris Bioscience, Glutamate (Metabotropic) Group III Receptor Agonist products

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