Chicago Sky Blue 6B

Cat. No. 0846

Chicago Sky Blue 6B C34H24N6Na4O16S4 [2610-05-1]

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Chemical Name: 6,6'-[(3,3-Dimethoxy[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[4-amino-5-hydroxy-1,3-napthalenedisulphonic acid] tetrasodium salt

Biological Activity

Potent inhibitor of L-glutamate uptake into synaptic vesicles. Allosterically inhibits macrophage migration inhibitory factor (MIF) (IC50 = 0.81 μM); inhibits MIF proinflammatory activity.

Technical Data

M.Wt:
992.79
Formula:
C34H24N6Na4O16S4
Solubility:
Soluble to 100 mM in water
Storage:
Store at RT
CAS No:
2610-05-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Bai et al (2012) A novel allosteric inhibitor of macrophage migration inhibitory factor (MIF). J.Biol.Chem. 287 30653. PMID: 22782901.

Roseth et al (1995) Uptake of L-glutamate into rat brain synaptic vesicles: effect of inhibitors that bind specifically to the glutamate transport. J.Neurochem. 65 96. PMID: 7790899.

Fonnum et al (1994) Inhibitors of amino acid uptake into vesicles. J.Neurochem. 63 Suppl. 1 S49A.

If you know of a relevant reference for Chicago Sky Blue 6B please let us know.

Citations are publications that use Tocris products. Selected citations for Chicago Sky Blue 6B include:

Bai et al (2012) A novel allosteric inhibitor of macrophage migration inhibitory factor (MIF). J Biol Chem 287 30653. PMID: 22782901.

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Keywords: Chicago Sky Blue 6B, supplier, Potent, inhibitors, inhibits, L-glutamate, reuptake, synaptic, vesicles, EAAT, Excitatory, Amino, Acid, Transporters, GLAST, GLT-1, Glutamate, Monoamine, Neurotransmitter, Blue6B, Tocris Bioscience, Glutamate Transporter Inhibitor products

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