CGS 12066B dimaleate

Cat. No. 0638

CGS 12066B dimaleate C17H17F3N4.2C4H4O4 [109028-10-6]

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Chemical Name: 7-Trifluoromethyl-4-(4-methyl-1-piperazinyl)pyrrolo[1,2-a]-quinoxaline dimaleate

Biological Activity

5-HT1B full agonist, 10-fold selective over 5-HT1A and 1000-fold selective over 5-HT2C receptors. Centrally active following systemic administration.

Technical Data

M.Wt:
566.49
Formula:
C17H17F3N4.2C4H4O4
Solubility:
Soluble to 5 mM in water and to 40 mM in DMSO
Purity:
>98 %
Storage:
Store at RT
CAS No:
109028-10-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Tomkins and O'Neill (2000) Effect of 5-HT1B receptor ligands on self-administration of ethanol in an operant procedure in rats. Pharmacol.Biochem.Behav. 66 129. PMID: 10837852.

Schoeffter and Hoyer (1989) Interaction of arylpiperazines with 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D receptors: do discriminatory 5-HT1B receptor ligands exist? Naunyn Schmiedebergs Arch.Pharmacol. 339 675. PMID: 2770889.

Neale et al (1987) Biochemical and pharmacological characterization of CGS 12066B, a selective serotonin-1B agonist. Eur.J.Pharmacol. 136 1. PMID: 3496228.

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Citations are publications that use Tocris products. Selected citations for CGS 12066B dimaleate include:

Khatri et al (2014) Lasting neurobehavioral abnormalities in rats after neonatal activation of serotonin 1A and 1B receptors: possible mechanisms for serotonin dysfunction in autistic spectrum disorders. Psychopharmacology (Berl) 231 1191. PMID: 23975037.

Maciag et al (2006) Evidence that the deficit in sexual behavior in adult rats neonatally exposed to citalopram is a consequence of 5-HT1 receptor stimulation during development. Brain Res 1125 171. PMID: 17101120.

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Keywords: CGS 12066B dimaleate, supplier, 5-HT1B, agonists, Serotonin, Receptors, 5-HT1, CGS12066B, dimaleate, Tocris Bioscience, 5-HT1B Receptor Agonist products

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