Cat. No. 0744

Ceramide C20H39NO3 [3102-57-6]

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Chemical Name: N-Acetylsphingosine

Biological Activity

A potent modulator of cell proliferation and differentiation. Activates protein phosphatase-1 (PP1) and -2A (PP2A), as well as ceramide-activated protein phosphatase (CAPP) in vitro.

Technical Data

Soluble to 100 mM in ethanol and to 100 mM in DMSO
Desiccate at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Xie and Johnson (1997) Ceramide selectively decreases tau levels in differentiated PC12 cells through modulation of calpain I. J.Neurochem. 69 1020. PMID: 9282924.

Quintans et al (1994) Ceramide mediates the apoptotic response of WEHI 231 cells to anti-immunoglobulin, corticosteroids and irradiation. Biochem.Biophys.Res.Commun. 202 710. PMID: 8048941.

Dobowsky and Hannun (1992) Ceramide stimulates a cytosolic protein phosphatase. J.Biol.Chem. 267 5048. PMID: 1312082.

Kim et al (1991) Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor α and γ-interferon. J.Biol.Chem. 266 484. PMID: 1845977.

If you know of a relevant reference for Ceramide please let us know.

Citations are publications that use Tocris products. Selected citations for Ceramide include:

Samokhvalov et al (2015) PPARδ signaling mediates the cytotoxicity of DHA in H9c2 cells. Pharmacol Biochem Behav 232 44105. PMID: 25300478.

Do you know of a great paper that uses Ceramide from Tocris? If so please let us know.

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Keywords: Ceramide, supplier, Ser/Thr, protein, phosphatase, activators, Protein, Phosphatases, Tocris Bioscience, Protein Ser/Thr Phosphatases Activator products

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