Cat. No. 0744
Chemical Name: N-Acetylsphingosine
Biological ActivityA potent modulator of cell proliferation and differentiation. Activates protein phosphatase-1 (PP1) and -2A (PP2A), as well as ceramide-activated protein phosphatase (CAPP) in vitro.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Xie and Johnson (1997) Ceramide selectively decreases tau levels in differentiated PC12 cells through modulation of calpain I. J.Neurochem. 69 1020. PMID: 9282924.
Quintans et al (1994) Ceramide mediates the apoptotic response of WEHI 231 cells to anti-immunoglobulin, corticosteroids and irradiation. Biochem.Biophys.Res.Commun. 202 710. PMID: 8048941.
Dobowsky and Hannun (1992) Ceramide stimulates a cytosolic protein phosphatase. J.Biol.Chem. 267 5048. PMID: 1312082.
Kim et al (1991) Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor α and γ-interferon. J.Biol.Chem. 266 484. PMID: 1845977.
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Citations are publications that use Tocris products. Selected citations for Ceramide include:
Samokhvalov et al (2015) PPARδ signaling mediates the cytotoxicity of DHA in H9c2 cells. Pharmacol Biochem Behav 232 44105. PMID: 25300478.
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Keywords: Ceramide, supplier, Ser/Thr, protein, phosphatase, activators, Protein, Phosphatases, Tocris Bioscience, Protein Ser/Thr Phosphatases Activator products