LY 354740

Cat. No. 3246

LY 354740 C8H11NO4 [176199-48-7]

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Chemical Name: (1S,2S,5R,6S)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid

Biological Activity

Highly selective and potent agonist of group II mGlu receptors (EC50 values are 5.1 and 24.3 nM at mGlu2 and mGlu3 receptors respectively and > 100000 nM at mGlu4, mGlu7, mGlu1a and mGlu5a receptors). Displays antianxiety and antiaddictive activity in vivo. Orally and systemically active.

Technical Data

M.Wt:
185.18
Formula:
C8H11NO4
Solubility:
Soluble to 100 mM in 1eq. NaOH
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
176199-48-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Klodzinska et al (1999) Potential anti-anxiety, anti-addictive effects of LY 354740, a selective group II glutamate metabotropic receptors agonist in animal models. Neuropharmacology 38 1831. PMID: 10608278.

Helton et al (1998) Anxiolytic and side-effect profile of LY354740: a potent, highly selective, orally active agonist for group II metabotropic glutamate receptors. J.Pharmacol.Exp.Ther. 284 651. PMID: 9454811.

Schoepp et al (1997) LY354740 is a potent and highly selective group II metabotropic glutamate receptor agonist in cell expressing human glutamate receptors. Neuropharmacology 36 1. PMID: 9144636.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for LY 354740 include:

Copeland et al (2015) Neuronal activity patterns in the mediodorsal thalamus and related cognitive circuits are modulated by metabotropic glutamate receptors. Sci Rep 92 16. PMID: 25576798.

Yaeger and Trussell (2015) Single granule cells excite Golgi cells and evoke feedback inhibition in the cochlear nucleus. J Neurosci 35 4741. PMID: 25788690.

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View Related Products by Target

Keywords: LY 354740, supplier, Potent, selective, group, II, mGlur, agonists, Group, Receptors, mGlu2, mGluR2, mGlu3, mGluR3, Glutamate, Metabotropic, LY354740, Tocris Bioscience, Glutamate (Metabotropic) Group II Receptor Agonist products

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