SKF 96365 hydrochloride

Cat. No. 1147

SKF 96365 hydrochloride C22H26N2O3.HCl [130495-35-1]

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Chemical Name: 1-[2-(4-Methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl-1H-imidazole hydrochloride

Biological Activity

Store-operated Ca2+ entry (SOCE) inhibitor that inhibits STIM1. Also blocks TRPC channels, voltage-gated Ca2+ channels and potassium channels.

Technical Data

M.Wt:
402.92
Formula:
C22H26N2O3.HCl
Solubility:
Soluble to 100 mM in water
Purity:
>99 %
Storage:
Store at RT
CAS No:
130495-35-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Singh et al (2010) The transient receptor potential channel antagonist SKF96365 is a potent blocker of low-voltage-activated T-type calcium channels. Br.J.Pharmacol. 160 1464. PMID: 20590636.

Varnai et al (2009) STIM and Orai: the long-awaited constituents of store-operated calcium entry. TiPS 30 118. PMID: 19187978.

Merritt et al (1990) SK&F96365, a novel inhibitor of receptor-mediated calcium entry. Biochem.J. 271 515. PMID: 2173565.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for SKF 96365 hydrochloride include:

Alkhani et al (2014) Contribution of TRPC3 to store-operated calcium entry and inflammatory transductions in primary nociceptors. Proc Natl Acad Sci U S A 10 43. PMID: 24965271.

Kubota et al (2014) mGluR1-mediated excitation of cerebellar GABAergic interneurons requires both G protein-dependent and Src-ERK1/2-dependent signaling pathways. PLoS One 9 e106316. PMID: 25181481.

Hutchins et al (2013) Calcium release-dependent actin flow in the leading process mediates axophilic migration. Biochem J 33 11361. PMID: 23843509.

Soltoff and Lannon (2013) Activation of ERK1/2 by store-operated calcium entry in rat parotid acinar cells. PLoS One 8 e72881. PMID: 24009711.

Ben-Mabrouk and Tryba (2010) Substance P modulation of TRPC3/7 channels improves respiratory rhythm regularity and ICAN-dependent pacemaker activity. Mol Pain 31 1219. PMID: 20345918.

Fu and Pol (2010) Kisspeptin directly excites anorexigenic proopiomelanocortin neurons but inhibits orexigenic neuropeptide Y cells by an indirect synaptic mechanism. J Neurosci 30 10205. PMID: 20668204.

Kyriazis et al (2010) Stress-induced switch in Numb isoforms enhances Notch-dependent expression of subtype-specific transient receptor potential channel. J Biol Chem 285 6811. PMID: 20038578.

Hildebrand et al (2009) Functional coupling between mGluR1 and Cav3.1 T-type calcium channels contributes to parallel fiber-induced fast calcium signaling within Purkinje cell dendritic spines. J Neurosci 29 9668. PMID: 19657020.

Szikra et al (2009) Calcium homeostasis and cone signaling are regulated by interactions between calcium stores and plasma membrane ion channels. PLoS One 4 e6723. PMID: 19696927.

Shin et al (2008) Dendritic glutamate release produces autocrine activation of mGluR1 in cerebellar Purkinje cells. J Neuroinflammation 105 746. PMID: 18174329.

Huang et al (2004) Astrocyte glutamate transporters regulate metabotropic glutamate receptor-mediated excitation of hippocampal interneurons. J Neurosci 24 4551. PMID: 15140926.

Moneer et al (2003) Nitric oxide co-ordinates the activities of the capacitative and non-capacitative Ca2+-entry pathways regulated by vasopressin. Eur J Neurosci 370 439. PMID: 12459038.

Lim et al (2001) NAADP+ initiates the Ca2+ response during fertilization of starfish oocytes. FASEB J 15 2257. PMID: 11641253.

Do you know of a great paper that uses SKF 96365 hydrochloride from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: SKF 96365 hydrochloride, supplier, STIM1-mediated, Ca2+, influx, inhibitos, receptor-mediated, entry, Store, Operated, Calcium, Channels, STIM-Orai, Signaling, Signalling, Agents, General, SKF96365, hydrochloride, Tocris Bioscience, TRPC Blocker products

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