ATPA

Cat. No. 1107

ATPA C10H16N2O4 [140158-50-5]

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Chemical Name: (RS)-2-Amino-3-(3-hydroxy-5-tert-butylisoxazol-4-yl)propanoic acid

Biological Activity

A selective and potent GluR5 kainate receptor agonist (Ki = 4.3 nM), inactive at GluR6 (Ki > 1 mM) and only weakly active at AMPA receptors (GluR1-4) and the kainate receptors KA-2 and GluR7 (Ki values of 6 - 14 μM). Also available as part of the Kainate Receptor Tocriset™.

Technical Data

M.Wt:
228.25
Formula:
C10H16N2O4
Solubility:
Soluble to 10 mM in water and to 100 mM in 1eq. NaOH
Purity:
>98 %
Storage:
Desiccate at +4°C
CAS No:
140158-50-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Moldrich et al (1999) Excitotoxic injury profiles of low-affinity kainate receptor agonists in neuronal cultures. Eur.J.Pharmacol. 378 R1. PMID: 10478637.

Clarke et al (1997) A hippocampal GluR5 kainate receptor regulating inhibitory synaptic transmission. Nature 389 599. PMID: 9335499.

Matzen et al (1997) AMPA receptor agonists: synthesis, protolytic properties, and pharmacology of 3-isothiazole bioisasteres of glutamic acid. J.Med.Chem. 40 520. PMID: 9046343.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for ATPA include:

Song et al (2015) Minocycline does not affect long-term potentiation in the anterior cingulate cortex of normal adult mice. Front Pediatr 11 25. PMID: 25933605.

Randall et al (2011) Fast oscillatory activity induced by kainate receptor activation in the rat basolateral amygdala in vitro. Eur J Neurosci 33 914. PMID: 21255131.

Dargan et al (2009) ACET is a highly potent and specific kainate receptor antagonist: characterisation and effects on hippocampal mossy fibre function. Neuropharmacology 56 121. PMID: 18789344.

Xu et al (2006) Presynaptic regulation of the inhibitory transmission by GluR5-containing kainate receptors in spinal substantia gelatinosa. Mol Pain 2 29. PMID: 16948848.

Liu et al (2004) Astrocyte-mediated activation of neuronal kainate receptors. Mol Pain 101 3172. PMID: 14766987.

Do you know of a great paper that uses ATPA from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: ATPA, supplier, Selective, potent, GluR5, agonists, Glutamate, Kainate, Receptors, iGlur, Ionotropic, Tocris Bioscience, Kainate Receptor Agonist products

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