Cat. No. 1107
Chemical Name: (RS)-2-Amino-3-(3-hydroxy-5-tert-bu
Biological ActivityA selective and potent GluR5 kainate receptor agonist (Ki = 4.3 nM), inactive at GluR6 (Ki > 1 mM) and only weakly active at AMPA receptors (GluR1-4) and the kainate receptors KA-2 and GluR7 (Ki values of 6 - 14 μM). Also available as part of the Kainate Receptor Tocriset™.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Moldrich et al (1999) Excitotoxic injury profiles of low-affinity kainate receptor agonists in neuronal cultures. Eur.J.Pharmacol. 378 R1. PMID: 10478637.
Clarke et al (1997) A hippocampal GluR5 kainate receptor regulating inhibitory synaptic transmission. Nature 389 599. PMID: 9335499.
Matzen et al (1997) AMPA receptor agonists: synthesis, protolytic properties, and pharmacology of 3-isothiazole bioisasteres of glutamic acid. J.Med.Chem. 40 520. PMID: 9046343.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for ATPA include:
Randall et al (2011) Fast oscillatory activity induced by kainate receptor activation in the rat basolateral amygdala in vitro. Eur J Neurosci 33 914. PMID: 21255131.
Dargan et al (2009) ACET is a highly potent and specific kainate receptor antagonist: characterisation and effects on hippocampal mossy fibre function. Neuropharmacology 56 121. PMID: 18789344.
Xu et al (2006) Presynaptic regulation of the inhibitory transmission by GluR5-containing kainate receptors in spinal substantia gelatinosa. Mol Pain 2 29. PMID: 16948848.
Do you know of a great paper that uses ATPA from Tocris? If so please let us know.
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Keywords: ATPA, supplier, Selective, potent, GluR5, agonists, Glutamate, Kainate, Receptors, iGlur, Ionotropic, Tocris Bioscience, Kainate Receptor Agonist products
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