TCS PrP Inhibitor 13

Cat. No. 3238

TCS PrP Inhibitor 13 C15H11N3O3 [34320-83-7]

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Chemical Name: 2,4-Dihydro-5-(4-nitrophenyl)-2-phenyl-3H-pyrazol-3-one

Biological Activity

Antiprion agent. Potently inhibits protease-resistant prion protein (PrP-res) accumulation in two types of prion-infected mouse neuroblastoma (N2a) cell lines (IC50 = 3 nM).

Technical Data

M.Wt:
281.27
Formula:
C15H11N3O3
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
34320-83-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Kimata et al (2007) New series of antiprion compounds: pyrazolone derivatives have potent activity of inhibiting protease-resistant prion protein accumulation. J.Med.Chem. 50 5053. PMID: 17850126.

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Keywords: TCS PrP Inhibitor 13, supplier, Antiprion, agent, potently, inhibits, inhibitors, PrP-res, accumulation, Prion, Protein, Neuronal, Metabolism, TCSPrP, Inhibitor13, Tocris Bioscience, Neuronal Metabolism products

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