Cat. No. 3237
Biological ActivitySelective neuromedin B receptor (NMB-R, BB1) antagonist (Ki values are 216 and 18,264 nM for BB1 and BB2 receptors respectively). Displays no activity at a range of other receptors.
(Modifications: Disulfide bridge between 2 - 7, X-1 = D-Nal, Trp-4 = D-Trp, X-8 = Nal & C-terminal amide)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Milusheva et al (1998) Role of different bombesin receptor subtypes mediating contractile activity in cat upper gastrointestinal tract. Peptides 19 549. PMID: 9533644.
Ryan et al (1996) Pharmacological profiles of two bombesin analogues in cells transfected with human neuromedin B receptors. Eur.J.Pharmacol. 306 307. PMID: 8813645.
Orbuch et al (1993) Discovery of a novel class of neuromedin B receptor antagonists, substituted somatostatin analogues. Mol.Pharmacol. 44 841. PMID: 7901752.
If you know of a relevant reference for BIM 23042 please let us know.
Citations are publications that use Tocris products. Selected citations for BIM 23042 include:
Blais et al (2016) Gastrin-releasing peptide receptor mediates the excitation of preoptic GABAergic neurons by bombesin Neuroscience Letters 633 262. PMID: 27693662.
Do you know of a great paper that uses BIM 23042 from Tocris? If so please let us know.
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Keywords: BIM 23042, supplier, Selective, neuromedin, B, receptor, antagonists, NMB-R, BB1, NMB-Preferring, Neuromedin, B-Preferring, Bombesin, BIM23042, Tocris Bioscience, Bombesin Receptor Antagonist products
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