Carboxy-PTIO, potassium salt

Cat. No. 0772

Carboxy-PTIO, potassium salt C14H16KN2O4 [148819-94-7]

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Chemical Name: 2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide, potassium salt

Biological Activity

A stable, water-soluble free radical that reacts stoichiometrically with NO. Almost twice as strong an inhibitor as N(ω)-nitroarginine or N-methylarginine.

Technical Data

M.Wt:
315.38
Formula:
C14H16KN2O4
Solubility:
Soluble to 25 mM in ethanol and to 10 mM in water
Storage:
Desiccate at -20°C
CAS No:
148819-94-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Rand and Li (1995) Discrimination by the NO-trapping agent, carboxy-PTIO, between NO and the nitrergic transmitter but not between NO and EDRF. Br.J.Pharmacol. 116 1906. PMID: 8528578.

Tsunoda et al (1994) Vasodilator effect of carboxy-2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl in the coronary circulation: in vivo and in vitro studies. Eur.J.Pharmacol. 262 55. PMID: 7813579.

Akaike et al (1993) Antagonistic action of imidazolineoxy N-oxides against endothelium-derived relaxing factor/NO through a radical reaction. Biochemistry 32 827. PMID: 8422387.

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Citations are publications that use Tocris products. Selected citations for Carboxy-PTIO, potassium salt include:

Clark et al (2015) Selective activation of microglia facilitates synaptic strength. Cardiovasc Res 35 4552. PMID: 25788673.

Echeverría et al (2014) Endotoxin induces fibrosis in vascular endothelial cells through a mechanism dependent on transient receptor protein melastatin 7 activity. PLoS One 9 e94146. PMID: 24710004.

Jin et al (2012) Activation of the cGMP/Protein Kinase G Pathway by Nitric Oxide Can Decrease TRPV1 Activity in Cultured Rat Dorsal Root Ganglion Neurons. Korean J Physiol Pharmacol 16 211. PMID: 22802704.

Ormerod et al (2011) The role of vascular myoglobin in nitrite-mediated blood vessel relaxation. Br J Pharmacol 89 560. PMID: 20889759.

Quock et al (2011) The acute antinociceptive effect of HBO2 is mediated by a NO-cyclic GMP-PKG-KATP channel pathway in mice. Brain Res 1368 102. PMID: 20977894.

Ota et al (2010) Synaptic plasticity and NO-cGMP-PKG signaling regulate pre- and postsynaptic alterations at rat lateral amygdala synapses following fear conditioning. PLoS One 5 e11236. PMID: 20574537.

Ota et al (2010) Synaptic plasticity and NO-cGMP-PKG signaling coordinately regulate ERK-driven gene expression in the lateral amygdala and in the auditory thalamus following Pavlovian fear conditioning. Learn Mem 17 221. PMID: 20351057.

Ping and Schafe (2010) The NO-cGMP-PKG signaling pathway coordinately regulates ERK and ERK-driven gene expression at pre- and postsynaptic sites following LTP-inducing stimulation of thalamo-amygdala synapses. Neural Plast 2010 540940. PMID: 21461354.

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Keywords: Carboxy-PTIO, potassium salt, supplier, Stable, water-soluble, deactivators, NO, Nitric, Oxide, Signaling, Signalling, free, radical, Tocris Bioscience, Other Nitric Oxide products

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