Cat. No. 0323
Alternative Name: (S)-4CPG
Biological ActivityCompetitive group I metabotropic glutamate receptor antagonist, with selectivity for mGlu1a/1a over mGlu5a/5b. (RS)-4-Carboxyphenylglycine (Cat. No. 0321) and (R)-4-Carboxyphenylglycine (Cat. No. 0322) also available.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Doherty et al (1999) Antagonist activity of α-substituted 4-carboxyphenylglycine analogues at group I metabotropic glutamate receptors expressed in CHO cells. Br.J.Pharmacol. 126 205. PMID: 10051137.
Brabet et al (1995) Phenylglycine derivatives discriminate between mGluR1-and mGluR5-mediated responses. Neuropharmacology 34 895. PMID: 8532171.
Birse et al (1993) Phenylglycine derivatives as new pharmacological tools for investigating the role of metabotropic glutamate receptors in the central nervous system. Neuroscience 52 481. PMID: 7680790.
Eaton et al (1993) Competitive antagonism at metabotropic glutamate receptors by (S)-4-carboxyphenylglycine (CPG) and (RS)-α-methyl-4-carboxyphenylglycine (MCPG). Eur.J.Pharmacol. 244 195. PMID: 8381746.
If you know of a relevant reference for (S)-4-Carboxyphenylglycine please let us know.
Citations are publications that use Tocris products. Selected citations for (S)-4-Carboxyphenylglycine include:
Griffin et al (2015) Repeated cycles of chronic intermittent ethanol exposure increases basal glutamate in the nucleus accumbens of mice without affecting glutamate transport. Front Pharmacol 6 27. PMID: 25755641.
Mahler et al (2014) Modafinil attenuates reinstatement of cocaine seeking: role for cystine-glutamate exchange and metabotropic glutamate receptors. J Young Investig 19 49. PMID: 23017017.
Resch et al (2014) Augmented cystine-glutamate exchange by pituitary adenylate cyclase-activating polypeptide signaling via the VPAC1 receptor. Synapse. PMID: 25066643.
Overocker and Pfau (2012) Cytokine Production Modified by System X(c)- After PM10 and Asbestos Exposure. Proc Natl Acad Sci U S A 23 34. PMID: 23418405.
Liu et al (2007) Cystine-glutamate transporter SLC7A11 mediates resistance to geldanamycin but not to 17-(allylamino)-17-demethoxygeldanamycin. Mol Pharmacol 72 1637. PMID: 17875604.
Porter et al (2005) Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity. J Pharmacol Exp Ther 315 711. PMID: 16040814.
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Keywords: (S)-4-Carboxyphenylglycine, supplier, competitive, Group, I, mGlur, antagonists, weak, group, II, agonists, Competitive, Receptors, mGlu2, mGlu3, mGluR2, mGluR3, Glutamate, Metabotropic, mGlu1, mGlu5, mGluR1, mGluR5, Tocris Bioscience, Glutamate (Metabotropic) Group I Receptor Antagonist products
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