AGK 2

Cat. No. 3233

AGK 2 C23H13Cl2N3O2 [304896-28-4]

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Chemical Name: 2-Cyano-3-[[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide

Biological Activity

Selective inhibitor of SIRT2 (IC50 = 3.5 μM). Displays no activity at SIRT1 and SIRT3 at concentrations up to 40 μM. Reduces α-synuclein-mediated toxicity in in vitro and in vivo models of Parkinson's disease.

Technical Data

M.Wt:
434.27
Formula:
C23H13Cl2N3O2
Solubility:
Soluble to 10 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
304896-28-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Outeiro et al (2007) Sirtuin 2 inhibitors rescue α-synuclein-mediated toxicity in models of Parkinson's disease. Science 317 516. PMID: 17588900.

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Citations are publications that use Tocris products. Selected citations for AGK 2 include:

Newton et al (2014) Is SIRT2 required for necroptosis? Nature 506 E4. PMID: 24572428.

Snider et al (2013) Glucose and SIRT2 reciprocally mediate the regulation of keratin 8 by lysine acetylation. Adipocyte 200 241. PMID: 23358244.

Xu et al (2013) Temporal analysis of protein lysine acetylation during adipocyte differentiation. J Pharmacol Exp Ther 2 33. PMID: 23700550.

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Keywords: AGK 2, supplier, Selective, SIRT2, inhibitors, inhibits, Sirtuin, Sir2-like, Family, Deacetylases, AGK2, Tocris Bioscience, Sir 2-like Family Deacetylase Inhibitor products

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