[Lys5,MeLeu9,Nle10]-NKA(4-10)

Cat. No. 3228

[Lys5,MeLeu9,Nle10]-NKA(4-10) Asp-Lys-Phe-Val-Gly-Leu(N-methyl)-Nle-NH2

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Biological Activity

Highy selective and potent NK2 receptor agonist (IC50 = 6.1 nM). Induces contraction of the rat fundus and bladder (EC50 values are 117 and 10 nM respectively).

Technical Data

M.Wt:
804
Formula:
C39H65N9O9
Sequence:
DKFVGLX

(Modifications: Leu-6 = Leu(N-methyl), X = Nle & C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
137565-28-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Burcher et al (2008) Tachykinin NK2 receptor and functional mechanisms in human colon: changes with indomethacin and in diverticular disease and ulcerative colitis. J.Pharmacol.Exp.Ther. 324 170. PMID: 17959748.

Matuszek et al (1998) An investigation of tachykinin NK2 receptor subtypes in the rat. Eur.J.Pharmacol. 352 103. PMID: 9718274.

Chassaing et al (1991) Selective agonists of NK-2 binding sites highly active on rat portal vein (NK-3 bioassay). Neuropeptides 19 91. PMID: 1658676.

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Keywords: [Lys5,MeLeu9,Nle10]-NKA(4-10), supplier, Selective, NK2, agonists, Tachykinin, Receptors, Neurokinin, Tocris Bioscience, NK2 Receptor Agonist products

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