R 892

Cat. No. 3226

R 892 Ac-Lys-Arg-Pro-Pro-Gly-(αmethyl)Phe-Ser-DβNal-Ile

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Biological Activity

Potent and selective bradykinin B1 receptor antagonist (ID50 values are 2.8 and > 600 nM at B1 and B2 receptors respectively). Exhibits no intrinsic agonist activity and is resistant to aminopeptidase and kininase II (ACE) cleavage. Displays hypertensive activity in vivo.

Technical Data

M.Wt:
1154.37
Formula:
C58H83N13O12
Sequence:
KRPPGFSXI

(Modifications: Lys-1 = N-terminal Ac, Phe-6 = (αMe)Phe, X = DβNal)

Solubility:
Soluble to 2 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
229030-05-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Duka et al (2003) Mechanisms mediating the vasoactive effects of the B1 receptors of bradykinin. Hypertension 42 1021. PMID: 14557281.

Gobeil et al (1998) Kinin B1 receptor antagonists containing α-methyl-L-phenylalanine: in vitro and in vivo antagonistic activities. Hypertension 33 823.

Gobeil et al (1996) Structure-activity studies of B1 receptor related peptide. Hypertension 28 833. PMID: 8901831.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for R 892 include:

Mattis et al (2014) Frequency-dependent, cell type-divergent signaling in the hippocamposeptal projection. J Neurosci 34 11769. PMID: 25164672.

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Keywords: R 892, supplier, Potent, selective, B1, antagonists, Receptors, Bradykinin, R892, Tocris Bioscience, Bradykinin Receptor Antagonist products

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