Cat. No. 3226
Biological ActivityPotent and selective bradykinin B1 receptor antagonist (ID50 values are 2.8 and > 600 nM at B1 and B2 receptors respectively). Exhibits no intrinsic agonist activity and is resistant to aminopeptidase and kininase II (ACE) cleavage. Displays hypertensive activity in vivo.
(Modifications: Lys-1 = N-terminal Ac, Phe-6 = (αMe)Phe, X = DβNal)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Duka et al (2003) Mechanisms mediating the vasoactive effects of the B1 receptors of bradykinin. Hypertension 42 1021. PMID: 14557281.
Gobeil et al (1998) Kinin B1 receptor antagonists containing α-methyl-L-phenylalanine: in vitro and in vivo antagonistic activities. Hypertension 33 823.
Gobeil et al (1996) Structure-activity studies of B1 receptor related peptide. Hypertension 28 833. PMID: 8901831.
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Citations are publications that use Tocris products. Selected citations for R 892 include:
Mattis et al (2014) Frequency-dependent, cell type-divergent signaling in the hippocamposeptal projection. J Neurosci 34 11769. PMID: 25164672.
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Keywords: R 892, supplier, Potent, selective, B1, antagonists, Receptors, Bradykinin, R892, Tocris Bioscience, Bradykinin Receptor Antagonist products
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