TCS JNK 6o
Cat. No. 3222
Chemical Name: N-(4-Amino-5-cyano-6-ethoxy-2-pyrid
Biological ActivityATP-competitive c-Jun N-terminal kinase (JNK) inhibitor (IC50 values are 2, 4 and 52 nM for JNK1, JNK2 and JNK3 respectively). Displays > 1000 fold selectivity over other kinases, including ERK2 and p38. Inhibits c-Jun phosphorylation (EC50 = 920 nM) and prevents collagen-induced platelet aggregation in vitro.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Kauskot et al (2007) Involvement of the mirogen-activated protein kinase c-Jun NH2-terminal kinase 1 in thrombus formation. J.Biol.Chem. 282 31990. PMID: 17785464.
Szczepankiewicz et al (2006) Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity. J.Med.Chem. 49 3563. PMID: 16759099.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses TCS JNK 6o from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: TCS JNK 6o, supplier, TCSJNK6o, c-Jun, N-terminal, kinase, JNK, inhibitors, inhibits, JNK1, JNK2, JNK3, Tocris Bioscience, JNK/c-Jun Inhibitor products
Find multiple products by catalog number
New Products in this Area
Selective p38α/β inhibitor; orally bioavailableAX 15836
Potent and selective ERK5 inhibitorEicosapentaenoic Acid
Endogenous polyunsaturated fatty acid; stimulates ERK1/2 phosphorylationBIRB 796
High affinity and selective p38 kinase inhibitor
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.