CGP 36216 hydrochloride
Cat. No. 3219
Chemical Name: (3-Aminopropyl)ethylphosphinic acid hydrochloride
Biological ActivitySelective GABAB antagonist. Displays activity at presynaptic receptors; ineffective at GABAB postsynaptic receptors.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Ong et al (2001) CGP 36216 is a selective antagonist at GABAB presynaptic receptors in rat brain. Eur.J.Pharmacol. 415 191. PMID: 11274998.
Froestl et al (1995) Phosphinic acid analogues of GABA. 2. Selective, orally active GABAB antagonists. J.Med.Chem. 38 3313. PMID: 7650685.
If you know of a relevant reference for CGP 36216 hydrochloride please let us know.
Citations are publications that use Tocris products. Selected citations for CGP 36216 hydrochloride include:
Chen et al (2015) Morphine disinhibits glutamatergic input to VTA dopamine neurons and promotes dopamine neuron excitation. J Neurosci 4. PMID: 26208338.
Do you know of a great paper that uses CGP 36216 hydrochloride from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: CGP 36216 hydrochloride, supplier, CGP36216, hydrochloride, gabab, antagonists, presynaptic, selective, Tocris Bioscience, GABAB Receptor Antagonist products
Find multiple products by catalog number
New Products in this Area
Highly potent GPR183 (EBI2) agonistAR-C 69931 tetrasodium salt
Highly potent P2Y12 antagonistFTY 720
Potent S1P receptor agonist; also immunosuppressantCinacalcet hydrochloride
Calcium-sensing receptor (CaSR) allosteric agonist; also CYP2D2 inhibitor and Ca2+ channel blocker; orally bioavailableAMG 837 hemicalcium salt
Potent free fatty acid receptor 1 (FFA1/GPR40) partial agonistUMB 68
GHB receptor ligandAZD 1283
High affinity P2Y12 antagonistEx 26
Potent and selective S1P1 receptor antagonist
August 20 - 24, 2017
Paris , France