Cat. No. 0320
Alternative Name: (S)-4C3HPG
Biological ActivityCompetitive antagonist at group I mGlu1a/1a receptors, mixed effect at mGlu5a/5b receptors; agonist at group II metabotropic glutamate receptors. (RS)-4-Carboxy-3-hydroxyphenylglycine (Cat. No. 0310) also available.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Sekiyama et al (1996) Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes. Br.J.Pharmacol. 117 1493. PMID: 8730745.
Kingston et al (1995) Pharmacological analysis of 4-carboxyphenylglycine derivatives: comparison of effects mGluR1α and mGluR5a subtypes. Neuropharmacology 34 887. PMID: 8532170.
Hayashi et al (1994) Analysis of agonist and antagonist activities of phenylglycine derivatives for different cloned metabotropic glutamate receptor sub-types. J.Neurosci. 14 3370. PMID: 8182479.
Birse et al (1993) Phenylglycine derivatives as new pharmacological tools for investigating the role of metabotropic glutamate receptors in the central nervous system Neuroscience 52 481. PMID: 7680790.
If you know of a relevant reference for (S)-4-Carboxy-3-hydroxyphenylglycine please let us know.
Citations are publications that use Tocris products. Selected citations for (S)-4-Carboxy-3-hydroxyphenylglycine include:
Lee and Flavell (2014) Inhibition and enhancement of contextual fear memory destabilization. Front Behav Neurosci 8 144. PMID: 24808841.
Do you know of a great paper that uses (S)-4-Carboxy-3-hydroxyphenylglycine from Tocris? If so please let us know.
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Keywords: (S)-4-Carboxy-3-hydroxyphenylglycine, supplier, competitive, Group, I, antagonists, group, II, agonists, mGlur, Receptors, mGlu1, mGlu5, mGluR1, mGluR5, Glutamate, Metabotropic, mGlu2, mGlu3, mGluR2, mGluR3, Tocris Bioscience, Glutamate (Metabotropic) Group I Receptor Antagonist products