Cat. No. 3214
Chemical Name: 2-[(4,5-Dihydro-2-thiazolyl)thio]-1
Biological ActivityAntitumor agent. Inhibits tumor cell growth in a mutant p53- and p73-dependent manner in vitro and in vivo (IC50 = 4 μM). Transcriptionally activates expression of p53-responsive genes and induces activation of effector caspases 3 and 7.
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Certificate of Analysis / Product Datasheet / Safety Datasheet
Kravchenko et al (2008) Small-molecule RETRA suppresses mutant p53-bearing cancer cells through a p73-dependent salvage pathway. Proc.Natl.Acad.Sci.USA 105 6302.
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Keywords: RETRA hydrochloride, supplier, Antitumor, agent, suppresses, mutant, p53-bearing, Transcription, Factors, p73, Tocris Bioscience, p53 products