Cat. No. 3214
Chemical Name: 2-[(4,5-Dihydro-2-thiazolyl)thio]-1
Biological ActivityAntitumor agent. Inhibits tumor cell growth in a mutant p53- and p73-dependent manner in vitro and in vivo (IC50 = 4 μM). Transcriptionally activates expression of p53-responsive genes and induces activation of effector caspases 3 and 7.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Kravchenko et al (2008) Small-molecule RETRA suppresses mutant p53-bearing cancer cells through a p73-dependent salvage pathway. Proc.Natl.Acad.Sci.USA 105 6302.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses RETRA hydrochloride from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: RETRA hydrochloride, supplier, Antitumor, agent, suppresses, mutant, p53-bearing, Transcription, Factors, p73, Tocris Bioscience, p53 products
Find multiple products by catalog number
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.