Methylene Blue

Cat. No. 3213

Methylene Blue C16H18ClN3S [61-73-4]

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Chemical Name: 3,7-bis(Dimethylamino)phenazathionium chloride

Biological Activity

Biological stain and redox indicator. Inhibits tau filament formation (IC50 = 1.9 μM). Also inhibits soluble guanylyl cyclase.

Technical Data

M.Wt:
319.85
Formula:
C16H18ClN3S
Solubility:
Soluble to 10 mM in water and to 10 mM in DMSO
Storage:
Store at RT
CAS No:
61-73-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Taniguchi et al (2005) Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins. J.Biol.Chem. 280 7614. PMID: 15611092.

Hwang et al (1998) Comparison of two soluble guanylyl cyclase inhibitors, methylene boue and ODQ, on sodium nitroprusside-induced relaxation in guinea-pig trachea. Br.J.Pharmacol. 125 1158. PMID: 9863642.

Wischik et al (1996) Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines. Neurobiology 93 11213.

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Keywords: Methylene Blue, supplier, Biological, stain, Soluble, guanylyl, cyclases, inhibitors, inhibits, tau, filaments, aggregation, Reagents, sGC, Tubulin, Microtubules, Nitric, Oxide, Signaling, Signalling, Tocris Bioscience, Labels & Stain products

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