Cat. No. 3213
Chemical Name: 3,7-bis(Dimethylamino)phenazathioni
Biological ActivityBiological stain and redox indicator. Inhibits tau filament formation (IC50 = 1.9 μM). Also inhibits soluble guanylyl cyclase.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Taniguchi et al (2005) Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins. J.Biol.Chem. 280 7614. PMID: 15611092.
Hwang et al (1998) Comparison of two soluble guanylyl cyclase inhibitors, methylene boue and ODQ, on sodium nitroprusside-induced relaxation in guinea-pig trachea. Br.J.Pharmacol. 125 1158. PMID: 9863642.
Wischik et al (1996) Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines. Neurobiology 93 11213.
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Keywords: Methylene Blue, supplier, Biological, stain, Soluble, guanylyl, cyclases, inhibitors, inhibits, tau, filaments, aggregation, Reagents, sGC, Tubulin, Microtubules, Nitric, Oxide, Signaling, Signalling, Tocris Bioscience, Fluorescent Dyes, Labels & Stain products