CP 376395 hydrochloride
Cat. No. 3212
Chemical Name: N-(1-Ethylpropyl)-3,6-dimethyl-2-(2
Biological ActivityPotent and selective CRF1 receptor antagonist (Ki values are 12 and >10000 nM for CRF1 and CRF2 receptors respectively). Attenuates CRF-induced activation of the HPA axis in vivo following i.v. administration. Orally active.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Hollenstein et al (2013) Structure of class B GPCR corticotropin-releasing factor receptor 1. Nature 499 438. PMID: 23863939.
Chen et al (2008) 2-Aryloxy-4-alkylaminopyridines: discovery of novel corticotropin-releasing factor 1 antagonists. J.Med.Chem. 51 1385. PMID: 18288792.
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Citations are publications that use Tocris products. Selected citations for CP 376395 hydrochloride include:
Kean et al (2015) Conformational thermostabilisation of corticotropin releasing factor receptor 1. Mol Pain 5 11954. PMID: 26159865.
Boyson et al (2014) Social stress and CRF-dopamine interactions in the VTA: role in long-term escalation of cocaine self-administration. J Neurosci 34 6659. PMID: 24806691.
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June 14 - 17, 2017
Boston, MA, USA