5-Carboxamidotryptamine maleate

Cat. No. 0458

5-Carboxamidotryptamine maleate C11H13N3O.C4H4O4 [74885-72-6]

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Alternative Names: AH-21467, 5-CT

Biological Activity

5-HT1 agonist with high affinity at 5-HT1A, 5-HT1B , 5-HT1D, 5-ht5 and 5-HT7 receptors.

Technical Data

Soluble to 100 mM in water
>99 %
Desiccate at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Wood et al (2000) Antagonist activity of meta-chlorophenylpiperazine and partial agonist activity of 8-OH-DPAT at the 5-HT7 receptor. Eur.J.Pharmacol. 396 1. PMID: 10822046.

Nowak et al (1993) [3H]-5-carboxamidotryptamine labels 5HT1D binding sites in bovine substantia nigra. Br.J.Pharmacol. 109 1206. PMID: 8401931.

Beer et al (1992) An investigation of the 5-HT1D receptor binding affinity of 5-hydroxytryptamine, 5-carboxyamidotryptamine and sumatriptan in the central nervous system of seven species. Eur.J.Pharmacol. 213 193. PMID: 1325915.

Zifa and Fillion (1992) 5-Hydroxytryptamine receptors. Pharmacol.Rev. 44 401. PMID: 1359584.

If you know of a relevant reference for 5-Carboxamidotryptamine maleate please let us know.

Citations are publications that use Tocris products. Selected citations for 5-Carboxamidotryptamine maleate include:

Sargin et al (2016) Chronic social isolation reduces 5-HT neuronal activity via upregulated SK3 calcium-activated potassium channels Elife 5 e21416. PMID: 27874831.

Chien and Su (2015) 5-hydroxytryptamine has an endothelium-derived hyperpolarizing factor-like effect on coronary flow in isolated rat hearts. PLoS One 22 42. PMID: 26076928.

Montalbano et al (2015) Pharmacological Characterization of 5-HT1A Autoreceptor-Coupled GIRK Channels in Rat Dorsal Raphe 5-HT Neurons. Br J Pharmacol 10 e0140369. PMID: 26460748.

Gantz et al (2013) Spontaneous inhibitory synaptic currents mediated by a G protein-coupled receptor. Am J Physiol Renal Physiol 78 807. PMID: 23764286.

Kim et al (2013) Targeted inhibition of serotonin type 7 (5-HT7) receptor function modulates immune responses and reduces the severity of intestinal inflammation. Neuron 190 4795. PMID: 23554310.

Müller et al (2009) 5-hydroxytryptamine modulates migration, cytokine and chemokine release and T-cell priming capacity of dendritic cells in vitro and in vivo. PLoS One 4 e6453. PMID: 19649285.

Manzke et al (2009) Serotonin targets inhibitory synapses to induce modulation of network functions. Philos Trans R Soc Lond B Biol Sci 364 2589. PMID: 19651659.

Morecroft et al (1999) 5-hydroxytryptamine receptors mediating contraction in human small muscular pulmonary arteries: importance of the 5-HT1B receptor. J Immunol 128 730. PMID: 10516655.

Do you know of a great paper that uses 5-Carboxamidotryptamine maleate from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: 5-Carboxamidotryptamine maleate, supplier, high, affinity, 5ht5A, 5-HT7, 5-HT1, agonists, Serotonin, Receptors, 5-Hydroxytryptamine, 5-HT, 5-ht5, Non-Selective, AH21467, Tocris Bioscience, Non-selective 5-HT1 Agonist products

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