Swainsonine

Cat. No. 3208

Swainsonine C8H15NO3 [72741-87-8]

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Chemical Name: (1S,2R,8R,8aR)-Octahydro-1,2,8-indolizinetriol

Biological Activity

Inhibitor of α-mannosidase II which inhibits glycoprotein processing. Displays anticancer and immune modulatory properties.

Technical Data

M.Wt:
173.21
Formula:
C8H15NO3
Solubility:
Soluble to 50 mM in water
Storage:
Store at -20°C
CAS No:
72741-87-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Sun et al (2007) Inhibition of the growth of human gastric carcinoma in vivo and in vitro by swainsonine. Phytomedicine 14 353. PMID: 17097281.

Olden et al (1991) The potential importance of swainsonine in therapy for cancers and immunology. Pharmacol.Ther. 50 285. PMID: 1754603.

Tulsiani et al (1982) Swainsonine inhibits the biosynthesis of complex glycoproteins by inhibition of golgi mannosidase II. J.Biol.Chem. 257 7936. PMID: 6806288.

If you know of a relevant reference for Swainsonine please let us know.

Citations are publications that use Tocris products. Selected citations for Swainsonine include:

Tareen et al (2014) Design of a novel integration-deficient lentivector technology that incorporates genetic and posttranslational elements to target human dendritic cells. Mol Ther 22 575. PMID: 24419083.

Do you know of a great paper that uses Swainsonine from Tocris? If so please let us know.

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Keywords: Swainsonine, supplier, inhibitors, inhibits, α-mannosidase, alpha-mannosidase, II, Glycosylases, Carbohydrate, Metabolism, Tocris Bioscience, Glycosylase Inhibitor products

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