FCCP

Cat. No. 0453

FCCP C10H5F3N4O [370-86-5]

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Chemical Name: Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone

Biological Activity

A very potent uncoupler of oxidative phosphorylation in mitochondria.

Technical Data

M.Wt:
254.17
Formula:
C10H5F3N4O
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
370-86-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Connop et al (1999) Novel effects of FCCP [carbonyl cyanide p-(trifluoromethoxy)phenylhydrazone] on amyloid precursor protein processing. J.Neurochem. 72 1457. PMID: 10098849.

Heytler and Pritchard (1962) A new class of uncoupling agents - carbonyl cyanide phenylhydrazones. Biochem.Biophys.Res.Commun. 7 272. PMID: 13907155.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for FCCP include:

Choubey et al (2014) BECN1 is involved in the initiation of mitophagy: it facilitates PARK2 translocation to mitochondria. Autophagy 10 1105. PMID: 24879156.

Gerich et al (2009) H(2)O(2)-mediated modulation of cytosolic signaling and organelle function in rat hippocampus. J Pharmacol Exp Ther 458 937. PMID: 19430810.

Do you know of a great paper that uses FCCP from Tocris? If so please let us know.

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Keywords: FCCP, supplier, Oxidative, phosphorylation, uncoupler, Tocris Bioscience, Oxidative Phosphorylation products

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