Cat. No. 0453
Chemical Name: Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone
Biological ActivityA very potent uncoupler of oxidative phosphorylation in mitochondria.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Connop et al (1999) Novel effects of FCCP [carbonyl cyanide p-(trifluoromethoxy)phenylhydrazone] on amyloid precursor protein processing. J.Neurochem. 72 1457. PMID: 10098849.
Heytler and Pritchard (1962) A new class of uncoupling agents - carbonyl cyanide phenylhydrazones. Biochem.Biophys.Res.Commun. 7 272. PMID: 13907155.
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Citations are publications that use Tocris products. Selected citations for FCCP include:
Choubey et al (2014) BECN1 is involved in the initiation of mitophagy: it facilitates PARK2 translocation to mitochondria. Autophagy 10 1105. PMID: 24879156.
Gerich et al (2009) H(2)O(2)-mediated modulation of cytosolic signaling and organelle function in rat hippocampus. J Pharmacol Exp Ther 458 937. PMID: 19430810.
Do you know of a great paper that uses FCCP from Tocris? If so please let us know.
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Keywords: FCCP, supplier, Oxidative, phosphorylation, uncoupler, Tocris Bioscience, Oxidative Phosphorylation products
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