Cat. No. 3203

Celastrol C29H38O4 [34157-83-0]

Price and Availability

For Celastrol pricing & availability please select your country from the drop down menu:
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: (9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid

Biological Activity

Antioxidant and anti-inflammatory agent. Potently inhibits lipid peroxidation in mitochondria and inhibits TNF-α-induced NFκB activation. Also shown to inhibit topoisomerase II activity in vitro (IC50 = 7.41 μM).

Technical Data

Soluble to 100 mM in DMSO and to 75 mM in ethanol
>99 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet

Sethi et al (2007) Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-κB-regulated gene products and TAK1-mediated NF-κB activation. Blood 109 2727. PMID: 17110449.

Nagase et al (2003) Apoptosis induction in HL-60 cells and inhibition of topoisomerase II by triterpene celastrol. Biosci.Biotechnol.Biochem. 67 1883. PMID: 14519971.

Sassa et al (1990) The triterpene celastrol as a very potent inhibitor of lipid peroxidation in mitochondria. Biochem.Biophys.Res.Comms. 172 890.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Celastrol include:

Zwicker et al (2015) Interleukin 34: a new modulator of human and experimental inflammatory bowel disease. Clin Sci (Lond) 129 281. PMID: 25896238.

Do you know of a great paper that uses Celastrol from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: Celastrol, supplier, inhibitors, inhibits, TNF-α, TNF-alpha-induced, NF-κB, NF-kappaB, NF-kB, activation, Antioxidant, anti-inflammatory, Topoisomerase, II, Nuclear, Factor, Kappa, B, Cytokine, Signaling, Signalling, Transcription, Factors, DNA, Isomerases, Tocris Bioscience, NF-κB and IκB Inhibitor products

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

Immunology Guide

Immunology Product Listing

Our Immunology listing highlights over 190 products for immunology research. Request copy or view PDF today.

divider line

New Therapies and Challenges in Asthma

Written by Peter J. Barnes

Asthma Life Science Poster

Our Asthma poster highlights key pathways and new therapies used to treat asthma, including those currently in clinical development. Request copy today.

divider line

NF-κB Pathway

NF-κB Signaling Pathway

Signals through the NF-κB pathway are important in the inflammation and the adaptive and innate immune response. View pathway or download PDF today.

divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.