Cat. No. 0452
Chemical Name: Carbonyl cyanide 3-chlorophenylhydrazone
Biological ActivityWidely used uncoupler of oxidative phosphorylation.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Heytler and Pritchard (1962) A new class of uncoupling agents - carbonyl cyanide phenylhydrazones. Biochem.Biophys.Res.Commun. 7 272. PMID: 13907155.
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Citations are publications that use Tocris products. Selected citations for CCCP include:
Guo et al (2015) Use of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes (hiPSC-CMs) to Monitor Compound Effects on Cardiac Myocyte Signaling Pathways. Curr Protoc Chem Biol 7 141. PMID: 26331525.
Choubey et al (2014) BECN1 is involved in the initiation of mitophagy: it facilitates PARK2 translocation to mitochondria. Autophagy 10 1105. PMID: 24879156.
Chouhan et al (2010) Presynaptic mitochondria in functionally different motor neurons exhibit similar affinities for Ca2+ but exert little influence as Ca2+ buffers at nerve firing rates in situ. J Neurosci 30 1869. PMID: 20130196.
Do you know of a great paper that uses CCCP from Tocris? If so please let us know.
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Keywords: CCCP, supplier, Oxidative, phosphorylation, uncoupler, Tocris Bioscience, Oxidative Phosphorylation products
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