Dimebon dihydrochloride

Cat. No. 3201

Dimebon dihydrochloride C21H25N3.2HCl [97657-92-6]

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Alternative Names: Dimebone, Latrepirdine

Chemical Name: 2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridinyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride

Biological Activity

Non-selective antihistamine that displays cognitive enhancing abilities. Also displays high affinity for 5-HT (particularly 5-HT6 and 5-HT7), α-adrenergic, dopaminergic, AMPA and NMDA receptors, and L-type calcium channels. Does not inhibit acetylcholinesterase activity. Exhibits neuroprotective activity in cellular models of Alzheimer's and Huntington's disease and preserves cognitive function following administration to AF64A lesioned rats. Protects neurons against the neurotoxic action of β-amyloid fragment; shown to enhance autophagy in yeast and reduce intracellular Aβ42 levels.

Technical Data

Soluble to 100 mM in water and to 100 mM in DMSO
>98 %
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Bharadwaj et al (2012) Latrepirdine (Dimebon) enhances autophagy and reduces intracellular GFP-Aβ42 levels in yeast. J.Alzheimers Dis. 32 949. PMID: 22903131.

Giorgetti et al (2010) Cognition-enhancing properties of dimebon in a rat novel object recognition task are unlikely to be associated with acetylcholinesterase inhibition or N-methyl-D-aspartate receptor antagonism J.Pharm.Exp.Ther. 333 748.

Okun et al (2009) From anti-allergic to anti-Alzheimer's: molecular pharmacology of dimebon. Curr.Alzheimer Res. 7 97.

Schaffhauser et al (2009) Dimebon is a 5-HT6 antagonist with acute cognitive enhancing activities. Biochem.Pharmacol. 78 1035. PMID: 19549510.

Bachurin et al (2001) Antihistamine agent dimebon as a novel neuroprotector and a cognitive enhancer. Ann.N.Y.Acad.Sci. 939 425. PMID: 11462798.

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Keywords: Dimebon dihydrochloride, supplier, cognitive, enhancer, alzheimers, huntingtons, disease, non-selective, antihistamine, neuroprotectant, neuroprotective, beta-amyloid, b-amyloid, β-amyloid, Huntington's, Latrepirdine, amyloidbeta, amyloidb, amyloidβ, Tocris Bioscience, Amyloid β Peptide products

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