Dimebon dihydrochloride

Cat. No. 3201

Dimebon dihydrochloride C21H25N3.2HCl [97657-92-6]

Price and Availability

For Dimebon dihydrochloride pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Names: Dimebone, Latrepirdine

Chemical Name: 2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridinyl)ethyl]-1H-pyrido[4,3-b]indole dihydrochloride

Biological Activity

Non-selective antihistamine that displays cognitive enhancing abilities. Also displays high affinity for 5-HT (particularly 5-HT6 and 5-HT7), α-adrenergic, dopaminergic, AMPA and NMDA receptors, and L-type calcium channels. Does not inhibit acetylcholinesterase activity. Exhibits neuroprotective activity in cellular models of Alzheimer's and Huntington's disease and preserves cognitive function following administration to AF64A lesioned rats. Protects neurons against the neurotoxic action of β-amyloid fragment; shown to enhance autophagy in yeast and reduce intracellular Aβ42 levels.

Technical Data

M.Wt:
392.37
Formula:
C21H25N3.2HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
97657-92-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Bharadwaj et al (2012) Latrepirdine (Dimebon) enhances autophagy and reduces intracellular GFP-Aβ42 levels in yeast. J.Alzheimers Dis. 32 949. PMID: 22903131.

Giorgetti et al (2010) Cognition-enhancing properties of dimebon in a rat novel object recognition task are unlikely to be associated with acetylcholinesterase inhibition or N-methyl-D-aspartate receptor antagonism J.Pharm.Exp.Ther. 333 748.

Okun et al (2009) From anti-allergic to anti-Alzheimer's: molecular pharmacology of dimebon. Curr.Alzheimer Res. 7 97.

Schaffhauser et al (2009) Dimebon is a 5-HT6 antagonist with acute cognitive enhancing activities. Biochem.Pharmacol. 78 1035. PMID: 19549510.

Bachurin et al (2001) Antihistamine agent dimebon as a novel neuroprotector and a cognitive enhancer. Ann.N.Y.Acad.Sci. 939 425. PMID: 11462798.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses Dimebon dihydrochloride from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: Dimebon dihydrochloride, supplier, cognitive, enhancer, alzheimers, huntingtons, disease, non-selective, antihistamine, neuroprotectant, neuroprotective, beta-amyloid, b-amyloid, β-amyloid, Huntington's, Latrepirdine, amyloidbeta, amyloidb, amyloidβ, Tocris Bioscience, Amyloid β Peptide products

Quick Order

Find multiple products by catalog number

divider line

Neurodegeneration Research Product Guide

Neurodegeneration Product Guide

Our Neurodegeneration guide highlights over 275 products for neurodegeneration research. Request copy or view PDF today.

divider line

Alzheimer's Disease: Neurobiology and Drug Targets

Written by Alan Palmer

Alzheimer's Life Science Poster

Our Alzheimer's disease poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease. Request copy or view PDF today.

divider line

New Products in this Area

Pladienolide B

mRNA splicing inhibitor; antitumor

Lin28 1632

RNA binding protein Lin28 inhibitor; promotes mESC differentiation; also bromodomain inhibitor

Sign-up for new product e-alerts
divider line

LinkedIn Updates

Follow Tocris on LinkedIn

Follow us on LinkedIn!

Visit our LinkedIn page for the latest Tocris news, events and updates.