XAC

Cat. No. 3200

XAC C21H28N6O4.2HCl

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Alternative Name: Xanthine amine congener

Chemical Name: N-(2-Aminoethyl)-2-[4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)phenoxy]-acetamide dihydrochloride

Biological Activity

Adenosine receptor antagonist (IC50 values are 1.8 and 114 nM at A1 and A2 receptors respectively). Attenuates adenosine-induced vasodilation and exhibits proconvulsant activity in vivo.

Technical Data

M.Wt:
501.41
Formula:
C21H28N6O4.2HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Weiß and Grisshammer (2002) Purification and characterization of the human adenosine A2A receptor functionally expressed in Escherichia coli. Eur.J.Biochem. 269 82. PMID: 11784301.

Sawmiller et al (1994) Effects of xanthine amine congener on hypoxic coronary resistance and venous and epicardial adenosine concentrations. Cardiovasc.Res. 28 604. PMID: 8025903.

Morgan et al (1989) Potent convulsant actions of the adenosine receptor antagonist, xanthine amine congener (XAC) Life Sci. 45 719. PMID: 2779359.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for XAC include:

Stoddart et al (2015) Application of BRET to monitor ligand binding to GPCRs. Nat Methods 12 661. PMID: 26030448.

Kozma et al (2013) Characterization by flow cytometry of fluorescent, selective agonist probes of the A(3) adenosine receptor. Biochem Pharmacol 85 1171. PMID: 23376019.

Do you know of a great paper that uses XAC from Tocris? If so please let us know.

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Keywords: XAC, supplier, adenosine, receptors, antagonists, A1, A2, non-selective, Tocris Bioscience, Non-selective Adenosine Antagonist products

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