Cat. No. 3198
Chemical Name: 8-[4-[4-(4-Chlorophenzyl)piperazide
Biological ActivityAdenosine A2B receptor antagonist that displays > 17000-fold selectivity over other adenosine receptors (Ki values are 0.553, > 10000, > 10000 and > 10000 nM for A2B, A1, A2A and A3 receptors respectively).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Borrmann et al (2009) 1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specificity. J.Med.Chem. 52 3994. PMID: 19569717.
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Citations are publications that use Tocris products. Selected citations for PSB 603 include:
Long et al (2015) p73 engages A2B receptor signalling to prime cancer cells to chemotherapy-induced death. J Pharmacol Exp Ther 34 5152. PMID: 25659586.
Rao et al (2015) Adenosine Signaling Mediates Osteogenic Differentiation of Human Embryonic Stem Cells on Mineralized Matrices. Front Bioeng Biotechnol 3 185. PMID: 26618155.
Schneider et al (2015) Extracellular nucleotides as novel, underappreciated pro-metastatic factors that stimulate purinergic signaling in human lung cancer cells. Oncogene 14 201. PMID: 26597723.
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Keywords: PSB 603, supplier, selective, A2B, antagonists, Receptors, adenosines, PSB603, Tocris Bioscience, Adenosine A2B Receptor Antagonist products