Cat. No. 3198
Chemical Name: 8-[4-[4-(4-Chlorophenzyl)piperazide
Biological ActivityAdenosine A2B receptor antagonist that displays > 17000-fold selectivity over other adenosine receptors (Ki values are 0.553, > 10000, > 10000 and > 10000 nM for A2B, A1, A2A and A3 receptors respectively).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Borrmann et al (2009) 1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specificity. J.Med.Chem. 52 3994. PMID: 19569717.
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Citations are publications that use Tocris products. Selected citations for PSB 603 include:
Rao et al (2015) Adenosine Signaling Mediates Osteogenic Differentiation of Human Embryonic Stem Cells on Mineralized Matrices. Front Bioeng Biotechnol 3 185. PMID: 26618155.
Stoddart et al (2015) Application of BRET to monitor ligand binding to GPCRs. Nat Methods 12 661. PMID: 26030448.
Do you know of a great paper that uses PSB 603 from Tocris? If so please let us know.
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Keywords: PSB 603, supplier, selective, A2B, antagonists, Receptors, adenosines, PSB603, Tocris Bioscience, A2B Receptor Antagonist products