Cat. No. 3197

Polygodial C15H22O2 [6754-20-7]

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Chemical Name: (1R,4aS,8aS)-1,4,4a,5,6,7,8,8a-Octahydro-5,5,8a-trimethyl-1,2-naphthalenedicarboxaldehyde

Biological Activity

TRPA1 channel activator (EC50 = 400 nM) that is selective against TRPV1, TRPV2, TRPV3, TRPV4 and TRPM8 channels. Acts as an analgesic via desensitization of sensory neurons. Also exhibits antifungal activity via inhibition of mitochondrial ATPase.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
>97 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Escalera et al (2008) TRPA1 mediates the noxious effects of natural sesquiterpene deterrents. J.Biol.Chem. 283 24136. PMID: 18550530.

Matsuda et al (2002) Protective effect of polygodial and related compounds on ethanol-induced gastric mucosal lesions in rats: structural requirements and mode of action. Bioorg.Med.Chem.Letts. 12 477.

Lunde and Kubo (2000) Effect of polygodial on the mitochondrial ATPase of Saccharomyces cerevisiae. Antimicrob.Agents Chemother. 44 1943. PMID: 10858359.

If you know of a relevant reference for Polygodial please let us know.

Citations are publications that use Tocris products. Selected citations for Polygodial include:

Shi et al (2015) Alterations in serotonin, transient receptor potential channels and protease-activated receptors in rats with irritable bowel syndrome attenuated by Shugan decoction. Mol Cancer 21 4852. PMID: 25944998.

Do you know of a great paper that uses Polygodial from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: Polygodial, supplier, TRPA1, channel, activator, mitochondrial, ATPase, antifungal, inhibits, mitochondrial, ATPase, Tocris Bioscience, TRPA1 Activator products

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