Colchicine

Cat. No. 1364

Colchicine C22H25NO6 [64-86-8]

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Chemical Name: (S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide

Biological Activity

Plant-derived alkaloid that binds to tubulin and depolymerizes microtubules.

Technical Data

M.Wt:
399.44
Formula:
C22H25NO6
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at RT
CAS No:
64-86-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Bai et al (1996) Identification of cysteine 354 of β-tubulin as part of the binding site for the A ring of colchicine. J.Biol.Chem. 271 12639. PMID: 8647876.

Burns (1992) Analysis of the colchicine-binding site of β-tubulin. FEBS Lett. 297 205. PMID: 1544399.

Hastie (1991) Interactions of colchicine with tubulin. Pharmacol.Ther. 51 377. PMID: 1792241.

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Keywords: Colchicine, supplier, inhibitors, inhibits, tubulin, Tau, Tubulin, Microtubules, Mitosis, Tocris Bioscience, Microtubule products

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