[cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - hPancreatic Polypeptide

Cat. No. 1365

[cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - hPancreatic Polypeptide Gly-Pro-Ser-Gln-Pro-Thr-Tyr-Pro-Gly-Asp-Asn-Ala-Thr-Pro-Glu-Gln-Met-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-Arg-Tyr-Ile-Asn-Met-Ala-Aib-Arg-Gln-Arg-Tyr-NH2

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Biological Activity

Potent, selective peptide agonist for the neuropeptide Y Y5 receptor (IC50 values for inhibition of NPY binding to human Y5, Y1, Y2 and Y4 receptors are 0.24, 530, > 500, and 51 nM respectively, Ki at Y5 = 0.1 - 0.15 nM). Stimulates food intake in vivo.

Technical Data

M.Wt:
4207.67
Formula:
C183H281N57O54S2
Sequence:
GPSQPTYPGDNATPEQMARYYSALRRYINMAXRQRY

(Modifications: X = Aib, Tyr-36 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
313988-89-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Dumont et al (2005) BODIPYŽ-conjugated neuropeptide Y ligands: new fluorescent tools to tag Y1, Y2, Y4 and Y5 receptor subtypes. Br.J.Pharmacol. 146 1069. PMID: 16231000.

Cabrele et al (2000) The first selective agonist for the neuropeptide YY5 receptor increases food intake in rats. J.Biol.Chem. 275 36043. PMID: 10944518.

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Keywords: [cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - hPancreatic Polypeptide, supplier, Potent, selective, neuropeptide, Y, Y5, agonists, Neuropeptide, Receptors, neuropeptides, Tocris Bioscience, NPY Receptor Agonist products

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