GANT 61

Cat. No. 3191

GANT 61 C27H35N5 [500579-04-4]

Price and Availability

For GANT 61 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine

Biological Activity

GLI antagonist that inhibits GLI1 and GLI2-induced transcription (IC50 ~ 5 μM). Inhibits the hedgehog (Hh) signaling pathway downstream of SMO and SUFU causing GLI1 nuclear accumulation. Displays antiproliferative and antitumor activity in vivo. Inhibits the pluripotency factors Oct4, Sox-2, Nanog and c-Myc in pancreatic cancer stem cells.

Technical Data

M.Wt:
429.61
Formula:
C27H35N5
Solubility:
Soluble to 50 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
500579-04-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet

Fu et al (2012) GANT-61 inhibits pancreatic cancer stem cell growth in vitro and in NOD/SCID/IL2R gamma null mice xenograft. Cancer Lett. 330 22. PMID: 23200667.

Mazumdar et al (2011) Blocking Hedgehog survival signaling at the level of the GLI genes induces DNA damage and extensive cell death in human colon carcinoma cells. Cancer Res. 71 5904. PMID: 21747117.

Lauth et al (2007) Inhibition of GLI-mediated transcription and tumor cell growth by small molecule antagonists. Proc.Natl.Acad.Sci.USA 104 8455. PMID: 17494766.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for GANT 61 include:

Lim et al (2015) Mitochondria-derived reactive oxygen species drive GANT61-induced mesothelioma cell apoptosis. Oncotarget 6 1519. PMID: 25544756.

Do you know of a great paper that uses GANT 61 from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: GANT 61, supplier, GANT61, selective, GLI, Gli, antagonists, inhibitors, inhibits, hedgehog, Hh, signaling, signalling, pathways, Tocris Bioscience, Hedgehog Signaling Inhibitor products

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

Stem Cell Toolbox

80 Stem Cell modulators supplied pre-dissolved in DMSO

Tocriscreen Stem Cell  Toolbox

Includes many of the latest compounds available for stem cell research. Covers compounds for stem cell differentiation, signaling and reprogramming.

divider line

Stem Cells Review

Written by K. Clarke et al

Stem Cells Scientific Review

Our Stem Cells review gives an overview of the use of small molecules in the control of stem cell growth & differentiation and somatic cell reprogramming. Request copy or view PDF today.

divider line

New Products in this Area

G10

Activator of STING-dependent signaling

3',3'-cGAMP sodium salt

STING agonist

2',3'-cGAMP sodium salt

Endogenous high affinity STING agonist

c-Di-AMP sodium salt

Endogenous STING and DDX41 agonist; activates STING-dependent signaling

c-Di-GMP sodium salt

Endogenous STING and DDX41 agonist; activates STING-dependent signaling

CPYPP

DOCK2-Rac1 interaction inhibitor

Sign-up for new product e-alerts
divider line

LinkedIn Updates

Follow Tocris on LinkedIn

Follow us on LinkedIn!

Visit our LinkedIn page for the latest Tocris news, events and updates.