SB 699551

Cat. No. 3188

SB 699551 C34H45N3O.2HCl [864741-95-7]

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Chemical Name: N-[2-(Dimethylamino)ethyl]-N-[[4'-[[(2-phenylethyl)amino]methyl][1,1'-biphenyl]-4-yl]methyl]cyclopentanepropanamide dihydrochloride

Biological Activity

Selective 5-ht5a receptor antagonist (pKi values are 8.3, < 6.0, < 6.0, < 6.0, < 5.5 and < 5.5 for 5-ht5a, 5-HT1B/D, 5-HT2A, 5-HT2C, 5-HT1A and 5-HT7 receptors respectively).

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Technical Data

M.Wt:
584.66
Formula:
C34H45N3O.2HCl
Solubility:
Soluble to 25 mM in DMSO and to 10 mM in ethanol
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
864741-95-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Thomas et al (2006) SB-69951-A (3-cyclopentyl-N-[2-(dimethylamino)ethyl]-N-[(4'-{[(2-phenylethyl)amino]methyl}-4-biphenylyl)methyl]propanamide dihydrochloride), a novel 5-ht5A receptor-selective antagonist, enhances 5-HT neuronal function: evidence for an autoreceptor role for the 5-ht5A receptor in guinea pig brain. Neuropharmacology 51 566. PMID: 16846620.

Thomas (2006) 5-ht5A receptors as a therapeutic target. Pharmacol.Ther. 111 707. PMID: 16516972.

Corbett et al (2005) Discovery of a potent and selective 5-ht5A receptor antagonist by high-throughput chemistry. Bioorg.Med.Chem.letts. 15 4014.

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Keywords: SB 699551, supplier, Selective, 5-ht5A, antagonists, Serotonin, Receptors, 5-Hydroxytryptamine, SB699551, GlaxoSmithKline, GSK, Tocris Bioscience, 5-ht5 Receptor Antagonist products

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