Cat. No. 3162
Biological ActivityUrotensin-II (UT) receptor pure antagonist (pEC50 = 7.24). Displays no agonist activity unlike other U-II/URP analogs. Inhibits the action of U-II in the rat aorta ring assay.
(Modifications: X = Orn, Disulfide bridge between 2 - 7)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Diallo et al (2008) [Orn5]URP acts as a pure antagonist of urotensinergic receptors in rat cortical astrocytes. Peptides 29 813. PMID: 18082287.
Chatenet et al (2004) Structure-activity relationships and structural conformation of a novel urotensin II-related peptide. Peptides 25 1819. PMID: 15476952.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for [Orn5]-URP include:
Lee et al (2014) Urotensin II induces interleukin 8 expression in human umbilical vein endothelial cells. PLoS One 9 e90278. PMID: 24587311.
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Keywords: [Orn5]-URP, supplier, Urotensin-II, UT, receptor, antagonists, Receptors, Tocris Bioscience, Urotensin-II Receptor Antagonist products
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