Cat. No. 3145
Alternative Name: Lu 3-010
Chemical Name: 1,3-Dihydro-N,3,3-trimethyl-1-pheny
Biological ActivityPotent, selective inhibitor of the noradrenalin transporter (NET) (IC50 = 2.9 nM). Exhibits selectivity for NET against SERT (5-HT transporters) and DAT (dopamine transporters). Displays a similar structure but different pharmacological profile to citalopram (Cat. No. 1427).
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Eildal et al (2008) From the selective serotonin transporter inhibitor citalopram to the selective norepinephrine transporter inhibitor talopram: synthesis and structure-activity relationship studies. J.Med.Chem. 51 3045. PMID: 18429609.
Schou et al (2006) Synthesis and positron emission tomography evaluation of three norepinephrine transporter radioligands: [C-11]desipramine, [C-11]talopram and [C-11]talsupram. Mol.Imaging Biol. 8 1.
Bogeso et al (1985) 3-phenyl-1-indanamines. Potential antidepressant activity and potent inhibition of dopamine, norepinephrine, and serotonin uptake. J.Med.Chem. 28 1817. PMID: 2999402.
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Keywords: Talopram hydrochloride, supplier, potent, selective, inhibitors, inhibits, noradrenalin, epinephrine, adrenergics, transporters, net, Lu3-010, noradrenaline, Tocris Bioscience, Adrenergic Transporter Inhibitor products
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