Talopram hydrochloride

Cat. No. 3145

Talopram hydrochloride C20H25NO.HCl [7013-41-4]

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Alternative Name: Lu 3-010

Chemical Name: 1,3-Dihydro-N,3,3-trimethyl-1-phenyl-1-isobenzofuranpropanamine hydrochloride

Biological Activity

Potent, selective inhibitor of the noradrenalin transporter (NET) (IC50 = 2.9 nM). Exhibits selectivity for NET against SERT (5-HT transporters) and DAT (dopamine transporters). Displays a similar structure but different pharmacological profile to citalopram (Cat. No. 1427).

Technical Data

M.Wt:
331.88
Formula:
C20H25NO.HCl
Solubility:
Soluble to 50 mM in water and to 100 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
7013-41-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Eildal et al (2008) From the selective serotonin transporter inhibitor citalopram to the selective norepinephrine transporter inhibitor talopram: synthesis and structure-activity relationship studies. J.Med.Chem. 51 3045. PMID: 18429609.

Schou et al (2006) Synthesis and positron emission tomography evaluation of three norepinephrine transporter radioligands: [C-11]desipramine, [C-11]talopram and [C-11]talsupram. Mol.Imaging Biol. 8 1.

Bogeso et al (1985) 3-phenyl-1-indanamines. Potential antidepressant activity and potent inhibition of dopamine, norepinephrine, and serotonin uptake. J.Med.Chem. 28 1817. PMID: 2999402.

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Keywords: Talopram hydrochloride, supplier, potent, selective, inhibitors, inhibits, noradrenalin, epinephrine, adrenergics, transporters, net, Lu3-010, noradrenaline, Tocris Bioscience, Adrenergic Transporter Inhibitor products

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