Cat. No. 1132
Alternative Name: Harman
Chemical Name: 1-Methyl-9H-pyrido[3,4-b]indole
Biological ActivityProposed as the endogenous ligand for imidazoline binding sites. Binds to I1-sites in rat kidney (IC50 = 31 nM) and I2-sites (Ki = 49 nM). Produces dose-dependent hypotension in vivo that is reversed by efaroxan (Cat. No. 0792). Potent inhibitor of monoamine oxidase A and B (IC50 values are 0.5 and 5 μM respectively).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Musgrave and Badoer (2000) Harmane produces hypotension following microinjection into the RVLM: possible role of I1-imidazoline receptors. Br.J.Pharmacol. 129 1057. PMID: 10725251.
Ernsberger et al (1999) The I1-imidazoline receptor and its cellular signalling pathways. Ann.N.Y.Acad.Sci. 881 35. PMID: 10415895.
Hudson et al (1999) Harmane, norharmane and tetrahydro β-carboline have high affinity for rat imidazoline binding sites. Br.J.Pharmacol. 126 2P.
Glover et al (1982) β-Carbolines as selective monoamine oxidase inhibitors: in vivo implications. J.Neural Transm. 54 209. PMID: 7130973.
Merck Index 12 4646.
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Keywords: Harmane, supplier, MAO-A, MAO-B, inhibitors, inhibits, putative, endogenous, imidazolines, ligand, MAO, monoamine, oxygenases, oxidases, I1, I2, Tocris Bioscience, General Imidazoline Ligand products
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