K 114

Cat. No. 3144

K 114 C22H17BrO2 [872201-12-2]

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Chemical Name: 4,4'-[(2-Bromo-1,4-phenylene)di-(1E)-2,1-ethenediyl]bisphenol

Biological Activity

Potent amyloid fibril-specific fluorescent dye (EC50 = 20 - 30 nM). Exhibits minimal fluorescence in aqueous buffers and fluoresces brightly in the presence of Aβ, α-synuclein and tau in situ. (Optimum wavelength = 550 nm).

Technical Data

M.Wt:
393.27
Formula:
C22H17BrO2
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
872201-12-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

LeVine (2005) Mechanism of Aβ(1-40) fibril-induced fluorescence of (trans-trans)-1-bromo-2,5-bis(4-hydroxystyryl)benene (K114). Biochemistry 44 15937. PMID: 16313197.

Crystal et al (2003) A comparison of amyloid fibrillogenesis using the novel fluorescent compound K114. J.Neurochem. 86 1359. PMID: 12950445.

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Keywords: K 114, supplier, Amyloid, fibril-specific, fluorescent, dye, Fluorescent, Probes, Beta, Precursor, Protein, APP, Secretase, β-Amyloid, beta-Amyloid, b-amyloid, Peptides, K114, amyloidbeta, amyloidb, amyloidβ, Tocris Bioscience, Fluorescent Probe products

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