Cat. No. 3144
Chemical Name: 4,4'-[(2-Bromo-1,4-phenylene)di-(1E)
Biological ActivityPotent amyloid fibril-specific fluorescent dye (EC50 = 20 - 30 nM). Exhibits minimal fluorescence in aqueous buffers and fluoresces brightly in the presence of Aβ, α-synuclein and tau in situ. (Optimum wavelength = 550 nm).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
LeVine (2005) Mechanism of Aβ(1-40) fibril-induced fluorescence of (trans-trans)-1-bromo-2,5-bis(4-hydroxystyryl)benene (K114). Biochemistry 44 15937. PMID: 16313197.
Crystal et al (2003) A comparison of amyloid fibrillogenesis using the novel fluorescent compound K114. J.Neurochem. 86 1359. PMID: 12950445.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses K 114 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: K 114, supplier, Amyloid, fibril-specific, fluorescent, dye, Fluorescent, Probes, Beta, Precursor, Protein, APP, Secretase, β-Amyloid, beta-Amyloid, b-amyloid, Peptides, K114, amyloidbeta, amyloidb, amyloidβ, Tocris Bioscience, Fluorescent Probe products
Find multiple products by catalog number
New Products in this Area
Fluorescent VMAT2 substrateJanelia Fluor™ 646, SE
Cell permeable fluorescent dye; supplied as NHS esterJanelia Fluor™ 549, SE
Cell permeable fluorescent dye; supplied as NHS esterBis-ANS
Fluorescent probe for nonpolar cavities in proteins; used to detect Aβ fibresCyanine 5, SE
Red fluorescent dye for the labeling of amines2-NBDG
Fluorescent glucose uptake indicatorHoechst 33258
Fluorescent dye for labeling DNANeurosensor 521
Selective noradrenalin and dopamine fluorescent indicator
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.