KM 11060

Cat. No. 3143

KM 11060 C19H17Cl2N3O2S [774549-97-2]

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Chemical Name: 7-Chloro-4-[4-[4-chlorophenyl)sulfonyl]-1-piperazinyl]quinoline

Biological Activity

Corrects F508del-CFTR trafficking; increases the amount of functional CFTR at the plasma membrane (~75%). Shown to inhibit PDE5 activity.

Technical Data

Soluble to 100 mM in DMSO and to 10 mM in ethanol
>98 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Robert et al (2008) Structural analog of Sildenafil identified as a novel corrector of the F508del-CFTR trafficking defect. Mol.Pharmacol. 73 478. PMID: 17975008.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for KM 11060 include:

Zhao et al (2013) Important role of platelets in modulating endotoxin-induced lung inflammation in CFTR-deficient mice. J Neuroinflammation 8 e82683. PMID: 24367540.

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View Related Products by Product Action

Keywords: KM 11060, supplier, Corrects, F508del-CFTR, trafficking, Cl-, Channels, VSAC, Chloride, KM11060, pharmacochaperones, Tocris Bioscience, Chloride Channel products

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