Cat. No. 3143
Chemical Name: 7-Chloro-4-[4-[4-chlorophenyl)sulfo
Biological ActivityCorrects F508del-CFTR trafficking; increases the amount of functional CFTR at the plasma membrane (~75%). Shown to inhibit PDE5 activity.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Robert et al (2008) Structural analog of Sildenafil identified as a novel corrector of the F508del-CFTR trafficking defect. Mol.Pharmacol. 73 478. PMID: 17975008.
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Citations are publications that use Tocris products. Selected citations for KM 11060 include:
Zhao et al (2013) Important role of platelets in modulating endotoxin-induced lung inflammation in CFTR-deficient mice. J Neuroinflammation 8 e82683. PMID: 24367540.
Do you know of a great paper that uses KM 11060 from Tocris? If so please let us know.
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Keywords: KM 11060, supplier, Corrects, F508del-CFTR, trafficking, Cl-, Channels, VSAC, Chloride, KM11060, pharmacochaperones, Tocris Bioscience, CFTR products
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