VU 10010

Cat. No. 3141

VU 10010 C17H16ClN3OS [633283-39-3]

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Chemical Name: 3-Amino-N-[(4-chlorophenyl)methyl]-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide

Biological Activity

Selective allosteric potentiator of M4 acetylcholine receptors (EC50 values are 33 and 0.7 nM for ACh in the absence and presence of VU10010 respectively). Binds to an allosteric site on the receptor increasing affinity for ACh and coupling to G-proteins.

Technical Data

M.Wt:
345.85
Formula:
C17H16ClN3OS
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
633283-39-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Shirey et al (2008) An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission. Nat.Chem.Biol. 4 42. PMID: 18059262.

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Citations are publications that use Tocris products. Selected citations for VU 10010 include:

Bell et al (2015) Acetylcholine release in mouse hippocampal CA1 preferentially activates inhibitory-selective interneurons via α4β2* nicotinic receptor activation. PLoS One 9 115. PMID: 25918499.

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Keywords: VU 10010, supplier, Selective, allosteric, potentiator, M4, receptors, Muscarinic, Receptors, Acetylcholine, ACh, VU10010, M4, PAM, Tocris Bioscience, M4 Receptor Modulator products

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