Cat. No. 3141
Chemical Name: 3-Amino-N-[(4-chlorophenyl)methyl]-
Biological ActivitySelective allosteric potentiator of M4 acetylcholine receptors (EC50 values are 33 and 0.7 nM for ACh in the absence and presence of VU10010 respectively). Binds to an allosteric site on the receptor increasing affinity for ACh and coupling to G-proteins.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Shirey et al (2008) An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission. Nat.Chem.Biol. 4 42. PMID: 18059262.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for VU 10010 include:
Bell et al (2015) Acetylcholine release in mouse hippocampal CA1 preferentially activates inhibitory-selective interneurons via α4β2* nicotinic receptor activation. PLoS One 9 115. PMID: 25918499.
Do you know of a great paper that uses VU 10010 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: VU 10010, supplier, Selective, allosteric, potentiator, M4, receptors, Muscarinic, Receptors, Acetylcholine, ACh, VU10010, M4, PAM, Tocris Bioscience, M4 Receptor Modulator products
Find multiple products by catalog number
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.