RC 160

Cat. No. 3139

RC 160 D-Phe-Cys-Tyr-D-Trp-Lys-Val-Cys-Trp-NH2 (Disulfide bridge: 2 - 7)

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Alternative Name: Vapreotide

Biological Activity

Cyclic octapeptide somatostatin analog (Ki values are 0.7, 5.4, 30.9, 45 and > 1000 nM for sst5, sst2, sst3, sst4 and sst1 receptors respectively). More metabolically stable than somatostatin (Cat. No. 1157). Inhibits growth hormone release in vivo.

Technical Data

M.Wt:
1131.37
Formula:
C57H70N12O9S2
Sequence:
FCYWKVCW

(Modifications: Phe-1 = D-Phe, Trp-4 = D-Trp, Trp-8 = C-terminal amide, Disulfide bridge between 2 - 7)

Solubility:
Soluble to 0.20 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
103222-11-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Lahlou et al (2003) sst2 Somatostatin receptor inhibits cell proliferation through Ras- Rap1-, and B-raf-dependent ERK2 activation. J.Biol.Chem. 278 39356. PMID: 12878607.

Patel and Srikant (1994) Subtype selectivity of peptide analogs for all five coned human somatostatin receptors (hsstr 1-5). Endocrinology 135 2814. PMID: 7988476.

Karashima et al (1987) Effects of highly potent octapeptide analogs of somatostatin on growth hormone, insulin and glucagon release. Life Sci. 41 1011. PMID: 2886886.

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Keywords: RC 160, supplier, Somatostatin, sst, Receptors, RC160, Tocris Bioscience, Somatostatin (sst) Receptor Agonist products

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