2-Chloroadenosine

Cat. No. 3136

2-Chloroadenosine C10H12ClN5O4 [146-77-0]

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Alternative Name: 2-CADO

Chemical Name: 6-Amino-2-chloropurine riboside

Biological Activity

Metabolically stable analog of adenosine that behaves as an adenosine receptor agonist (Ki values are 300, 80 and 1900 nM for A1, A2A and A3 receptors respectively). Anticonvulsive in vivo.

Technical Data

M.Wt:
301.69
Formula:
C10H12ClN5O4
Solubility:
Soluble to 25 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
146-77-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Abdul-Ghani et al (1997) The protective effect of 2-chloroadenosine against the development of amygdala kindling and on amygdala-kindled seizures. Eur.J.Pharmacol. 326 7. PMID: 9178649.

Pourgholami et al (1997) Intra-amygdala infusion of 2-chloroadenosine suppresses amygdala-kindled seizures. Brain Res. 775 37. PMID: 9439826.

Mathot et al (1996) Pharmacokinetic-haemodynamic relationships of 2-chloroadenosine at adenosine A1 and A2a receptors in vivo. Br.J.Pharmacol. 118 369. PMID: 8735640.

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Keywords: 2-Chloroadenosine, supplier, adenosines, receptors, agonists, Non-Selective, 2CADO, Tocris Bioscience, Non-selective Adenosine Agonist products

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