Cat. No. 3136
Alternative Name: 2-CADO
Chemical Name: 6-Amino-2-chloropurine riboside
Biological ActivityMetabolically stable analog of adenosine that behaves as an adenosine receptor agonist (Ki values are 300, 80 and 1900 nM for A1, A2A and A3 receptors respectively). Anticonvulsive in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Abdul-Ghani et al (1997) The protective effect of 2-chloroadenosine against the development of amygdala kindling and on amygdala-kindled seizures. Eur.J.Pharmacol. 326 7. PMID: 9178649.
Pourgholami et al (1997) Intra-amygdala infusion of 2-chloroadenosine suppresses amygdala-kindled seizures. Brain Res. 775 37. PMID: 9439826.
Mathot et al (1996) Pharmacokinetic-haemodynamic relationships of 2-chloroadenosine at adenosine A1 and A2a receptors in vivo. Br.J.Pharmacol. 118 369. PMID: 8735640.
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Citations are publications that use Tocris products. Selected citations for 2-Chloroadenosine include:
Nowak et al (2010) The A2aR adenosine receptor controls cytokine production in iNKT cells. Front Cell Neurosci 40 682. PMID: 20039304.
Do you know of a great paper that uses 2-Chloroadenosine from Tocris? If so please let us know.
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Keywords: 2-Chloroadenosine, supplier, adenosines, receptors, agonists, Non-Selective, 2CADO, Tocris Bioscience, Non-selective Adenosine Agonist products
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