Cat. No. 3135
Chemical Name: 6-(Cyclohexylmethoxy)-9H-purin-2-am
Biological ActivityCyclin-dependent kinase (cdk) 1 and cdk2 inhibitor (Ki values are 5 and 12 μM respectively). Inhibits growth of human tumor cells in vitro (mean GI50 = 13 μM). Also inhibits DNA topoisomerase II ATPase activity (IC50 = 300 μM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Jensen et al (2005) Substituted purine analogues define a novel structural class of catalytic topoisomerase II inhibitors. Cancer Res. 65 7470. PMID: 16103101.
Knockaert et al (2002) Pharmacological inhibitors of cyclin-dependent kinases. TiPS 23 417. PMID: 12237154.
Arris et al (2000) Identification of novel purine and pyrimidine cyclin-dependent kinase inhibitors with distinct molecular interactions and tumor cell growth inhibition profiles. J.Med.Chem. 43 2797. PMID: 10956187.
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Citations are publications that use Tocris products. Selected citations for NU 2058 include:
Goonesekere et al (2014) A meta analysis of pancreatic microarray datasets yields new targets as cancer genes and biomarkers. PLoS One 9 e93046. PMID: 24740004.
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Keywords: NU 2058, supplier, Cdk1, cdk2, Topoisomerase, II, inhibits, inhibitors, Cyclin-Dependent, Protein, Kinases, DNA, Isomerases, NU2058, Tocris Bioscience, Cyclin-Dependent Protein Kinase Inhibitor products
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