Cat. No. 1355
Chemical Name: N-cyano-N'-(1,1-dimethylpropyl)-N''-3-
Biological ActivityPotent Kir6 (KATP) channel opener (EC50 for relaxation of rat aorta = 7.5 nM). Binds to SUR2A and SUR2B with high affinity (Kd values are 17 and 3 nM respectively).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Ashcroft and Gribble (2000) New windows on the mechanism of action of KATP channel openers. TiPS 21 439. PMID: 11121575.
Buckner et al (2000) Pharmacological and molecular analysis of ATP-sensitive K+ channels in the pig and human detrusor. Eur.J.Pharmacol. 400 287. PMID: 10988346.
Gross et al (1999) Stoichiometry of potassium channel opener action. Mol.Pharmacol. 56 1370. PMID: 10570067.
Higdon et al (1997) Tissue and species variation in the vascular receptor binding of 3H-P1075, a potent KATP opener vasodilator. J.Pharmacol.Exp.Ther. 280 255. PMID: 8996204.
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Citations are publications that use Tocris products. Selected citations for P1075 include:
Baczkó et al (2005) Plasma membrane KATP channel-mediated cardioprotection involves posthypoxic reductions in calcium overload and contractile dysfunction: mechanistic insights into cardioplegia. FASEB J 19 980. PMID: 15774423.
Do you know of a great paper that uses P1075 from Tocris? If so please let us know.
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Keywords: P1075, supplier, Potent, KATP, channel, openers, Potassium, KIR, Channels, Inward, Rectifier, K+, Kir6, Tocris Bioscience, Inward Rectifier Potassium (Kir) Channel Activator products