Cat. No. 0448

Calpeptin C20H30N2O4 [117591-20-5]

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Chemical Name: N-Benzyloxycarbonyl-L-leucylnorleucinal

Biological Activity

Potent, cell-permeable inhibitor of the Ca2+-dependent protease, calpain. Prevents collagen- and thrombin-induced platelet aggregation, probably by blocking calpain induced phospholipase C and thromboxane synthase activation. Potent cathepsin L inhibitor. Recently shown to preferentially inhibit a subset of protein-tyrosine phosphatases.

Technical Data

Soluble to 100 mM in DMSO
Desiccate at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Schoenwaelder and Burridge (1999) Evidence for a calpeptin-sensitive protein-tyrosine phosphatase upstream of the small GTPase Rho. J.Biol.Chem. 274 14359. PMID: 10318859.

Mehdi (1991) Cell-penetrating inhibitors of calpain. TiBS 16 150. PMID: 1877091.

Sasaki et al (1990) Inhibitory effect of di-and tripeptidyl aldehydes on calpains and cathepsins. J.Enzyme Inhib. 3 195. PMID: 2079636.

Tsujinaka et al (1988) Synthesis of a new cell penetrating calpain inhibitor (calpeptin). Biochem.Biophys.Res.Commun. 153 1201. PMID: 2839170.

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Citations are publications that use Tocris products. Selected citations for Calpeptin include:

Machado et al (2015) Involvement of calpains in adult neurogenesis: implications for stroke. J Biol Chem 9 22. PMID: 25698931.

Rivera-Pagán et al (2015) Up-regulation of TREK-2 potassium channels in cultured astrocytes requires de novo protein synthesis: relevance to localization of TREK-2 channels in astrocytes after transient cerebral ischemia. PLoS One 10 e0125195. PMID: 25886567.

Wang et al (2015) MFN2 couples glutamate excitotoxicity and mitochondrial dysfunction in motor neurons. J Pharmacol Exp Ther 290 168. PMID: 25416777.

Redpath et al (2014) Calpain cleavage within dysferlin exon 40a releases a synaptotagmin-like module for membrane repair. Mol Biol Cell 25 3037. PMID: 25143396.

Chen et al (2013) Nerve injury increases GluA2-lacking AMPA receptor prevalence in spinal cords: functional significance and signaling mechanisms. Pflugers Arch 347 765. PMID: 24030012.

Amadoro et al (2006) NMDA receptor mediates tau-induced neurotoxicity by calpain and ERK/MAPK activation. Proc Natl Acad Sci U S A 103 2892. PMID: 16477009.

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Keywords: Calpeptin, supplier, Calpain, cathepsin, L, inhibitors, inhibits, Proteinases, Proteases, Ca2+Sensitive, Protease, modulators, Calcium-Sensitive, Ca2+, Signaling, Signalling, Tocris Bioscience, Calcium-Sensitive Protease Modulator Inhibitor products

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