Cat. No. 3131
Chemical Name: 2-(2-Chlorophenyl)-2-(methylamino)c
Biological ActivityNon-competitive NMDA receptor antagonist (EC50 values are 13.6 and 17.6 μM for NR1/NR2A and NR1/NR2B subunit combinations respectively). Dissociative anesthetic. S-enantiomer (Cat. No. 4379) also available.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Liu et al (2001) Modulation of NMDA receptor function by ketamine and magnesium: part I. Anesth.Pharmacol. 92 1173.
Pallares et al (1995) Effects of ketamine, a noncompetitive NMDA antagonist, on the acquisition of the lever-press response in rats. Physiol.Behav. 57 389. PMID: 7716221.
Anis et al (1983) The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N-methyl-aspartate. Br.J.Pharmacol. 79 565. PMID: 6317114.
If you know of a relevant reference for Ketamine hydrochloride please let us know.
Citations are publications that use Tocris products. Selected citations for Ketamine hydrochloride include:
Rzeski et al (2001) Glutamate antagonists limit tumor growth. Oncotarget 98 6372. PMID: 11331750.
Do you know of a great paper that uses Ketamine hydrochloride from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Ketamine hydrochloride, supplier, Non-competitive, NMDA, receptor, antagonists, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, Dissociative, anesthetic, Tocris Bioscience, Ketamine and Metabolite products
Find multiple products by catalog number
New Products in this Area
Histone H3 peptideDBHDA
Reagent for synthetic biology; converts cysteine to dehydroalanineH3K4(Me3) (1-20)
Histone H3 peptide; substrate for methyltransferase/demethylase enzymesH3K4(Me) (1-20)
Histone H3 peptide; substrate for methyltransferase/demethylase enzymesH3K27(Me3) (15-34)
Histone H3 peptide; substrate for methyltransferase/demethylase enzymesH3K27(Me2) (15-34)
Histone H3 peptide; substrate for methyltransferase/demethylase enzymesH3K27(Me) (15-34)
Histone H3 peptide; substrate for demethylase/methyltransferase enzymesF 127 (20% solution in DMSO)
Photocrosslinker for hydrogelsGA3-AM
Gibberellin-analog (GA3) chemical dimerizer; cell permeableBicine
General purpose bufferACES
Buffer widely used in Western blottingCORM 2
Carbon monoxide-releasing molecule(S)-Norketamine hydrochloride
NMDA receptor modulator; analgesic2S,6S-Hydroxynorketamine hydrochloride
Decreases D-serine (a NMDA co-agonist); antidepressant2R,6R-Hydroxynorketamine hydrochloride
Enhances AMPA currents; decreases D-serine (a NMDA co-agonist); lacks ketamine-related side effects(R)-Norketamine hydrochloride
NMDA receptor modulator; analgesicHaXS8
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.