Cat. No. 3131
Chemical Name: 2-(2-Chlorophenyl)-2-(methylamino)c
Biological ActivityNon-competitive NMDA receptor antagonist (EC50 values are 13.6 and 17.6 μM for NR1/NR2A and NR1/NR2B subunit combinations respectively). Dissociative anesthetic. S-enantiomer (Cat. No. 4379) also available.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Liu et al (2001) Modulation of NMDA receptor function by ketamine and magnesium: part I. Anesth.Pharmacol. 92 1173.
Pallares et al (1995) Effects of ketamine, a noncompetitive NMDA antagonist, on the acquisition of the lever-press response in rats. Physiol.Behav. 57 389. PMID: 7716221.
Anis et al (1983) The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N-methyl-aspartate. Br.J.Pharmacol. 79 565. PMID: 6317114.
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Citations are publications that use Tocris products. Selected citations for Ketamine hydrochloride include:
Rzeski et al (2001) Glutamate antagonists limit tumor growth. Oncotarget 98 6372. PMID: 11331750.
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Keywords: Ketamine hydrochloride, supplier, Non-competitive, NMDA, receptor, antagonists, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, Dissociative, anesthetic, Tocris Bioscience, NMDA Receptor Antagonist products
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Potent NMDA receptor antagonist; NR2A selective
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